ArticlePLoS computational biology2022
Evidence for influenza and RSV interaction from 10 years of enhanced surveillance in Nha Trang, Vietnam, a modelling study.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- The limitations of non-mechanistic methods for characterizing pathogen-pathogen interactions: A simulation study.PLoS computational biology · 2026Article
- Interactions between zoonotic pathogens and infectious disease spread: Why understanding mechanisms and modelling matters more than ever.Biosafety and health · 2025Review
- Characterizing potential interaction between respiratory syncytial virus and seasonal influenza in the U.S.Epidemics · 2025Article
- The Role of Viral Interference in Shaping RSV Epidemics Following the 2009 H1N1 Influenza Pandemic.Influenza and other respiratory viruses · 2025Article
- The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus.Nature communications · 2025Article
- Characterizing the interactions between influenza and respiratory syncytial viruses and their implications for epidemic control.Nature communications · 2024Article
- Seasonality and Co-Detection of Respiratory Viral Infections Among Hospitalised Patients Admitted With Acute Respiratory Illness-Valencia Region, Spain, 2010-2021.Influenza and other respiratory viruses · 2024Article
- RSV vaccination as the optimal prevention strategy for older adults.Le infezioni in medicina · 2024Review
- Transient increased risk of influenza infection following RSV infection in South Africa: findings from the PHIRST study, South Africa, 2016-2018.BMC medicine · 2023Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Influenza and Respiratory Syncytial Virus (RSV) interact within their host posing the concern for impacts on heterologous viruses following vaccination. We aimed to estimate the population level impact of their interaction. We developed a dynamic age-stratified two-pathogen mathematical model that includes pathogen interaction through competition for infection and enhanced severity of dual infections. We used parallel tempering to fit its parameters to 11 years of enhanced hospital-based surveillance for acute respiratory illnesses (ARI) in children under 5 years old in Nha Trang, Vietnam. The data supported either a 41% (95%CrI: 36-54) reduction in susceptibility following infection and for 10.0 days (95%CrI 7.1-12.8) thereafter, or no change in susceptibility following infection. We estimate that co-infection increased the probability for an infection in <2y old children to be reported 7.2 fold (95%CrI 5.0-11.4); or 16.6 fold (95%CrI 14.5-18.4) in the moderate or low interaction scenarios. Absence of either pathogen was not to the detriment of the other. We find stronger evidence for severity enhancing than for acquisition limiting interaction. In this setting vaccination against either pathogen is unlikely to have a major detrimental effect on the burden of disease caused by the other.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.