Evidence map›Paper›PMID 35749524›Full record

ArticlePloS one2022

Ischemic stroke in patients that recover from COVID-19: Comparisons to historical stroke prior to COVID-19 or stroke in patients with active COVID-19 infection.

Naveed Akhtar, Fatma Abid, Rajvir Singh, Saadat Kamran, Yahia Imam, Salman Al-Jerdi, Sarah Salamah, Rand Al Attar, Muhammad Yasir, Hammad Shabir and 4 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Observational
  2. Article
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  4. Article
  5. Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Questionnaire-Based Study.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Naveed AkhtarThe Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Fatma AbidInfectious Diseases Section, Medicine Department, Hamad Medical Corporation, Doha, Qatar.
Rajvir SinghCardiology Research, Hamad Medical Corporation, Doha, Qatar.
Saadat KamranThe Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Yahia ImamThe Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.ORCID 0000-0003-4623-733X
Salman Al-JerdiWeill Cornell Medical College, Doha, Qatar.
Sarah SalamahInfectious Diseases Section, Medicine Department, Hamad Medical Corporation, Doha, Qatar.
Rand Al AttarInfectious Diseases Section, Medicine Department, Hamad Medical Corporation, Doha, Qatar.
Muhammad YasirEmergency Department, Hamad Medical Corporation, Doha, Qatar.
Hammad ShabirMedicine Department, Hamad Medical Corporation, Doha, Qatar.
Deborah MorganThe Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Sujatha JosephThe Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Muna AlMaslamaniInfectious Diseases Section, Medicine Department, Hamad Medical Corporation, Doha, Qatar.
Ashfaq ShuaibUniversity of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-3380-7068
Hamad Medical Corporation · QAUniversity of Alberta · CAWeill Cornell Medical College in Qatar · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeUnderstanding the relationship of COVID-19 to stroke is important. We compare characteristics of pre-pandemic historical stroke (Pre-C), cases in acute COVID infection (Active-C) and in patients who have recovered from COVID-19 infection (Post-C).

methodsWe interrogated the Qatar stroke database for all stroke admissions between Jan 2019 and Feb 2020 (Pre-C) to Active-C (Feb2020-Feb2021) and Post-C to determine how COVID-19 affected ischemic stroke sub-types, clinical course, and outcomes prior to, during and post-pandemic peak. We used the modified Rankin Scale (mRS) to measure outcome at 90-days (mRS 0-2 good recovery and mRS 3-6 as poor recovery). For the current analysis, we compared the clinical features and prognosis in patients with confirmed acute ischemic stroke.

resultsThere were 1413 cases admitted (pre-pandemic: 1324, stroke in COVID-19: 46 and recovered COVID-19 stroke: 43). Patients with Active-C were significantly younger, had more severe symptoms, fever on presentation, more ICU admissions and poor stroke recovery at discharge when compared to Pre-C and Post-C. Large vessel disease and cardioembolic disease was significantly more frequent in Active-C compared to PRE-C or post-C.

conclusionsStroke in Post-C has characteristics similar to Pre-C with no evidence of lasting effects of the virus on the short-term. However, Active-C is a more serious disease and tends to be more severe and have a poor prognosis.

Indexed as

Brain IschemiaCOVID-19Ischemic StrokeStrokeHumansPandemicsTreatment Outcome

Identifiers

PMID35749524
PMCPMC9232148
OpenAlexW4283399591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.