ArticleScience immunology2022
FOXP3 exon 2 controls T
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 60 citations in OpenAlex.
- How I Treat: Transplantation for primary immune regulatory diseases and inflammatory disorders.Journal of human immunity · 2026Article
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Targeting FOXP3 and Regulatory T Cells in Systemic Lupus Erythematosus: Emerging Therapeutic Strategies and Clinical Prospects.Journal of cellular biochemistry · 2026Review
- RNA splicing in health and disease.Molecular biomedicine · 2026Review
- Review
- First Comprehensive Analysis of Full-Length and Δ2 Foxp3 Isoforms Distribution in PBMCs from Healthy Volunteers.Biomolecules · 2026Article
- An early protective effect of IL-9 in murine systemic lupus erythematosus.ImmunoHorizons · 2026Article
- SRSF3 determines TScience advances · 2026Article
- Defects in CD8bioRxiv : the preprint server for biology · 2026Article
- CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.The Journal of clinical investigation · 2026Article
- Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes.Journal of diabetes investigation · 2026Article
- Review
- Evaluation ofCurrent protein & peptide science · 2026Article
- Inborn errors of regulatory T-cell differentiation and function.The Journal of allergy and clinical immunology · 2025Review
- Novel non-coding FOXP3 transcript isoform associated to potential transcriptional interference in human regulatory T cells.RNA biology · 2025Article
- Cellular and molecular mechanisms of seahorse male pregnancy.Nature ecology & evolution · 2025Article
- Review
- Reprogramming intratumoral TScience immunology · 2025Article
- Alternative Splicing in Tumorigenesis and Cancer Therapy.Biomolecules · 2025Review
- Review
Corrections and comments
- Commented on by
Authors and funding
23 authors at 4 institutions in 2 countries.
Jianguang DuDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4632-6212
Qun WangDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Shuangshuang YangDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0871-6356
Si ChenDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-3820-1065
Yongyao FuDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sabine SpathCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.ORCID 0000-0002-2689-1951
Phillip DomeierCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.ORCID 0000-0002-9937-8251
David HaginAllen Institute for Immunology, Seattle, WA 98109, USA.ORCID 0000-0003-2702-1031
Stephanie Anover-SombkeAllen Institute for Immunology, Seattle, WA 98109, USA.ORCID 0000-0002-8530-8068
Maya HaouiliDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sheng LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Jun WanDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-9286-6562
Lei HanDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-9088-2403
Juli LiuDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Lei YangDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Neel SanganiDepartment of BioHealth Informatics, School of Informatics and Computing, Indiana University-Purdue University, Indianapolis, IN 46202, USA.
Yujing LiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-3223-769X
Xiongbin LuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-7987-9825
Sarath Chandra JangaDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7351-6268
Mark H KaplanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2923-8245
Troy R TorgersonAllen Institute for Immunology, Seattle, WA 98109, USA.ORCID 0000-0003-3489-5036
Steven F ZieglerCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.ORCID 0000-0003-0657-5529
Baohua ZhouDepartment of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-1156-4517
Indiana University School of MedicineBenaroya Research InstituteUniversity of Washington · USShenzhen University · CN
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7MThe role of PU.1 in T helper cell heterogeneityR01AI057459 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 2005 to 2025
$8.2MTSLP in Th2 Immunity and Allergic Airway InflammationR01AI085046 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI ZHOU, BAOHUA · 2010 to 2019
$3.8MTargeting the IL-2/regulatory T cell axis for autoimmune disease prevention in realistic animal modelsR01AI136475 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J, ZIEGLER, STEVEN F · 2018 to 2022
$3.4MA FOXP3 complex that controls human regulatory T cell functionR01AI112323 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI ZIEGLER, STEVEN F · 2015 to 2019
$2.0MFOXP3 ΔE2 Isoform in Treg Function and Pathophysiology of LupusR21AI159804 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI ZHOU, BAOHUA · 2021 to 2022
$436kFOXP3 Regulates RNA Alternative Splicing in TregsR21AI110773 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI ZHOU, BAOHUA · 2015 to 2016
$429kNCI NIH HHS P30 CA082709NIAID NIH HHS R01 AI057459NIAID NIH HHS R01 AI085046NIAID NIH HHS R01 AI112323NIAID NIH HHS R01 AI136475NIAID NIH HHS R21 AI110773NIAID NIH HHS R21 AI159804NIDDK NIH HHS U54 DK106846
Abstract
Differing from the mouse
Indexed as
AutoimmunityT-Lymphocytes, RegulatoryAnimalsExonsForkhead Transcription FactorsHumansMiceProtein IsoformsForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseProtein Isoforms
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.