Evidence map›Paper›PMID 35749501›Full record

ArticleScience advances2022

The molecular impact of life in an indoor environment.

Alexander A Aksenov, Rodolfo A Salido, Alexey V Melnik, Caitriona Brennan, Asker Brejnrod, Andrés Mauricio Caraballo-Rodríguez, Julia M Gauglitz, Franck Lejzerowicz, Delphine K Farmer, Marina E Vance and 2 more

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexander A AksenovSkaggs of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-9445-2248
Rodolfo A SalidoCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA.
Alexey V MelnikSkaggs of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.
Caitriona BrennanCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-3943-6701
Asker BrejnrodSkaggs of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.
Andrés Mauricio Caraballo-RodríguezSkaggs of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-5499-2728
Julia M GauglitzSkaggs of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-3146-2489
Franck LejzerowiczCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3195-032X
Delphine K FarmerDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-6470-9970
Marina E VanceDepartment of Mechanical Engineering, University of Colorado Boulder, Boulder, CO 80309, USA.ORCID 0000-0003-0940-0353
Rob KnightCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-0975-9019
Pieter C DorresteinSkaggs of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-3003-1030

Funding

TrainingP41GM103484 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANDEIRA, NUNO · 2012 to 2018
$8.7M
Unified Computation Tools for Natural Products ResearchR01GM107550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COTTRELL, GARRISON W, GERWICK, WILLIAM HENRY · 2013 to 2025
$8.2M
NIGMS NIH HHS P41 GM103484NIGMS NIH HHS R01 GM107550
6 · The paper itself

Abstract

The chemistry of indoor surfaces and the role of microbes in shaping and responding to that chemistry are largely unexplored. We found that, over 1 month, people's presence and activities profoundly reshaped the chemistry of a house. Molecules associated with eating/cooking, bathroom use, and personal care were found throughout the entire house, while molecules associated with medications, outdoor biocides, and microbially derived compounds were distributed in a location-dependent manner. The house and its microbial occupants, in turn, also introduced chemical transformations such as oxidation and transformations of foodborne molecules. The awareness of and the ability to observe the molecular changes introduced by people should influence future building designs.

Identifiers

PMID35749501
PMCPMC9232106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.