ArticleAnnals of neurology2022
"Ependymal-in" Gradient of Thalamic Damage in Progressive Multiple Sclerosis.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 63 citations in OpenAlex.
- The effect of ibudilast on thalamic volume in progressive multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Trial
- Periventricular gradient pathology is linked to ependymal reactivity and cell adhesion disruption in multiple sclerosis.Nature neuroscience · 2026Article
- Cortical lesions in multiple sclerosis: 25 years of progress, remaining challenges and future directions.Nature reviews. Neurology · 2026Review
- Review
- Interthalamic adhesion alterations in multiple sclerosis: associations with thalamic damage and cognition.Journal of neurology · 2026Article
- Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis.Brain : a journal of neurology · 2026Article
- Abnormal B-Cell Exosome Proapoptotic and Antiapoptotic Cargo in Multiple Sclerosis: Potential Implication in Progressive Disease Biology.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- A CSF disease-associated macrophage signature defines progressive multiple sclerosis.Journal of neuroinflammation · 2026Article
- ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Investigating the association between grey matter hypoperfusion and atrophy in multiple sclerosis using arterial spin labelling.Brain communications · 2026Article
- Subcortical microglial inflammation is uniquely linked to subpial cortical demyelination in multiple sclerosis.NeuroImage. Clinical · 2026Article
- Article
- Quantitative Susceptibility Mapping of Deep Grey Matter in MS: Association With Clinical Scores and Brain Volume Measures.Brain and behavior · 2025Article
- Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids.Nature communications · 2025Article
- Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2025Article
- Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Neurodegeneration correlates of iron-related lesions and leptomeningeal inflammation in multiple sclerosis clinical subtypes.Neuroradiology · 2025Article
- Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability.Annals of clinical and translational neurology · 2025Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptomeningeal and perivenular infiltrates are important contributors to cortical grey matter damage and disease progression in multiple sclerosis (MS). Whereas perivenular inflammation induces vasculocentric lesions, leptomeningeal involvement follows a subpial "surface-in" gradient. To determine whether similar gradient of damage occurs in deep grey matter nuclei, we examined the dorsomedial thalamic nuclei and cerebrospinal fluid (CSF) samples from 41 postmortem secondary progressive MS cases compared with 5 non-neurological controls and 12 controls with other neurological diseases. CSF/ependyma-oriented gradient of reduction in NeuN
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.