ArticleCurrent HIV research2022
Association of Inflammatory Biomarkers and Cardiovascular Risk Scores in an Italian Cohort of HIV Positive Patient Undergoing Antiretroviral Therapy.
Article in Current HIV research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Cytokines assets in PLWH in two-drug dolutergravir based or three-drug antiretroviral regimen.BMC infectious diseases · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral algorithms have been developed to predict cardiovascular risk (CVR) over time, however, none of them seem to be accurate when applied to HIV patients.
objectiveThe aim of this study was to assess plasma inflammatory biomarkers in relation to multiple CVR scores (FRS, ASCVD, PROCAM and the DAD-5 Years-Estimated-Risk) in an Italian cohort of HIV patients undergoing a combined Antiretroviral Therapy (cART).
methodsWe enrolled HIV patients undergoing cART without any change in the HIV-related pharmacological therapy over the last 48 weeks. Demographic and anamnestic data were collected, and a biochemical panel including the following biomarkers was collected: CRP, Cystatin-C, microalbuminuria, IL-18, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN- γ. CVR scores were obtained for each patient and compared to the biochemical panel to assess statistical correlation.
results90 Caucasian HIV patients were enrolled. Assessment of CVR scores showed FRS values of 6.98 ± 6.11%, ASCVD 7.18 ± 6.25%, PROCAM 6.7 ± 7.4%, and DAD-5 Years Estimated Risk 3.10 ± 3.41%. We found correlations between the levels of circulating cytokines measured and the cardiovascular risk prediction scores.
conclusionOur data showed that the values of selected inflammatory biomarkers strongly correlate with the CVR scores, suggesting that they can be employed as reliable predictors of cardiovascular disease in HIV patients. The routine use of selected biomarkers associated with systemic inflammation could be a valid and readily available tool for clinicians to assess and monitor cardiovascular risk in HIV patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.