Evidence map›Paper›PMID 35748352›Full record

ArticleAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine2022

Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism.

Anthony J Weekes, Jaron D Raper, Alyssa M Thomas, Kathryn Lupez, Carly A Cox, Dasia Esener, Jeremy S Boyd, Jason T Nomura, Jillian Davison, Patrick M Ockerse and 4 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Quality of life 1 month after acute pulmonary embolism in emergency department patients.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2023
    Article
  9. Article
  10. Electrocardiographic findings associated with early clinical deterioration in acute pulmonary embolism.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Anthony J WeekesDepartment of Emergency Medicine, Atrium Health's Carolinas Medical Center (Carolinas Medical Center is the Central Site of the Pulmonary Embolism Short-term Outcomes Registry (PESCOR) consortium), Charlotte, North Carolina, USA.ORCID 0000-0001-9309-7910
Jaron D RaperDepartment of Emergency Medicine, Atrium Health's Carolinas Medical Center (Carolinas Medical Center is the Central Site of the Pulmonary Embolism Short-term Outcomes Registry (PESCOR) consortium), Charlotte, North Carolina, USA.
Alyssa M ThomasDepartment of Emergency Medicine, Atrium Health's Carolinas Medical Center (Carolinas Medical Center is the Central Site of the Pulmonary Embolism Short-term Outcomes Registry (PESCOR) consortium), Charlotte, North Carolina, USA.
Kathryn LupezDepartment of Emergency Medicine, Atrium Health's Carolinas Medical Center (Carolinas Medical Center is the Central Site of the Pulmonary Embolism Short-term Outcomes Registry (PESCOR) consortium), Charlotte, North Carolina, USA.
Carly A CoxDepartment of Emergency Medicine, Atrium Health's Carolinas Medical Center (Carolinas Medical Center is the Central Site of the Pulmonary Embolism Short-term Outcomes Registry (PESCOR) consortium), Charlotte, North Carolina, USA.
Dasia EsenerDepartment of Emergency Medicine Kaiser Permanente, San Diego, California, USA.
Jeremy S BoydDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jason T NomuraDepartment of Emergency Medicine, Christiana Care, Newark, Delaware, USA.
Jillian DavisonDepartment of Emergency Medicine, Orlando Health, Orlando, Florida, USA.
Patrick M OckerseDivision of Emergency Medicine, University of Utah Health, Salt Lake City, Utah, USA.
Stephen LeechDepartment of Emergency Medicine, Orlando Health, Orlando, Florida, USA.
Eric AbramsDepartment of Emergency Medicine Kaiser Permanente, San Diego, California, USA.
Christopher KellyDivision of Emergency Medicine, University of Utah Health, Salt Lake City, Utah, USA.
Nathaniel S O'ConnellDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Carolinas Medical Center · USKaiser Permanente San Diego Medical Center · USOrlando Health · USUniversity of Utah · USChristiana Care Health System · USHouston Methodist · USTufts Medical Center · USVanderbilt University Medical Center · USWake Forest University · US

Funding

Short-term Clinical Deterioration After Acute Pulmonary EmbolismR01HS025979 · AHRQ · CAROLINAS MEDICAL CENTER · PI WEEKES, ANTHONY J · 2018 to 2020
$1.0M
AHRQ HHS R01 HS025979
6 · The paper itself

Abstract

objectivesWe sought to determine associations of early electrocardiogram (ECG) patterns with clinical deterioration (CD) within 5 days and with RV abnormality (abnlRV) by echocardiography in pulmonary embolism (PE).

methodsIn this prospective, multicenter study of newly confirmed PE patients, early echocardiography and initial ECG were examined. Initial ECG patterns included lead-specific ST-segment elevation (STE) or depression (STD), T-wave inversion (TWI), supraventricular tachycardia (SVT), sinus tachycardia, and right bundle branch block as complete (cRBBB) or incomplete (iRBBB). We defined CD as respiratory failure, hypotension, dysrhythmia, cardiac arrest, escalated PE intervention, or death within 5 days. We calculated odds ratios (ORs) for CD and abnlRV with univariate and full multivariate models in the presence of other variables.

resultsOf 1676 patients, 1629 (97.2%) had both ECG and GDE; 415/1676 (24.7%) had CD, and 529/1629 (32.4%) had abnlRV. AbnlRV had an OR for CD of 4.25 (3.35, 5.38). By univariable analysis, the absence of abnormal ECG patterns had OR for CD and abnlRV of 0.34 (0.26, 0.44; p < 0.001) and 0.24 (0.18, 0.31; p < 0.001), respectively. By multivariable analyses, one ECG pattern had a significant OR for CD: SVT 2.87 (1.66, 5.00). Significant ORS for abnlRV were: TWI V

conclusionsSVT was an independent predictor of CD. TWI V

Indexed as

Clinical DeteriorationPulmonary EmbolismAcute DiseaseElectrocardiographyElectrolytesHumansProspective StudiesTachycardia, SinusElectrolytes

Identifiers

PMID35748352
PMCPMC9796434
OpenAlexW4283464724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.