Evidence map›Paper›PMID 35748131›Full record

ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2022

Ultrasound-guided fine-needle aspiration cytology significantly improved mycetoma diagnosis.

E E Siddig, O El Had Bakhait, M El Nour Hussein Bahar, E Siddig Ahmed, S M Bakhiet, M Motasim Ali, O Babekir Abdallah, R Ahmed Hassan, A Verbon, W W J van de Sande and 1 more

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In one paragraph

Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Mycetoma.PLoS neglected tropical diseases · 2026
    Review
  3. Article
  4. Review
  5. Mycetoma in Somalia: an updated literature review.Annals of medicine and surgery (2012) · 2025
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

E E SiddigThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
O El Had BakhaitThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
M El Nour Hussein BaharThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
E Siddig AhmedThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
S M BakhietThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
M Motasim AliThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
O Babekir AbdallahThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
R Ahmed HassanThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
A VerbonDepartment of Medical Microbiology and Infectious Diseases, ErasmusMC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
W W J van de SandeDepartment of Medical Microbiology and Infectious Diseases, ErasmusMC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-8652-8783
A H FahalThe Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.ORCID https://orcid.org/0000-0003-4922-7321
University of Khartoum · SDErasmus MC · NLUniversity of Medical Sciences and Technology · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUltrasound (US)-guided fine-needle aspiration cytology (US-FNAC) has improved the diagnosis of many malignancies, infections and other diseases as it is safe, simple, quick and accurate. In mycetoma, it is assumed that this technique may have a better diagnostic yield than the conventional FNAC as it can accurately identify the optimal site for the aspiration.

objectiveTo compare the diagnostic yield of conventional FNAC with US-FNAC.

methodsThis descriptive cross-sectional hospital-based study included 80 patients with clinically suspected mycetoma.

resultsOf the 80 patients included, 35 proved to have actinomycetoma, and 37 had eumycetoma based on surgical biopsies, histopathological examination and the culture of grains. Eight patients appeared to have no mycetoma. For actinomycetoma diagnosis, the US-guided FNAC improved sensitivity to 97% and negative predictive value (NPV) to 83% compared to the conventional FNAC, which had 63% sensitivity; and NPV of 28%. No improvement was found for specificity. For eumycetoma, the conventional FNAC had 86.5% sensitivity, 100% specificity, 100% PPV and 37.5% NPV. The US-FNAC for the diagnosis of eumycetoma had 100% sensitivity and specificity. CONCLUSIONS AND RELEVANCE: The obtained results showed that US-FNAC is better than the conventional FNAC with lower false-negative results. It can accurately distinguish between the two types of mycetoma, allowing rapid initiation of proper treatment. The technique can be used in rural areas with low resources and for epidemiological surveys as a quick screening tool for patients suspected of mycetoma.

Indexed as

MycetomaBiopsy, Fine-NeedleCross-Sectional StudiesHumansSensitivity and SpecificityUltrasonography, Interventional

Identifiers

PMID35748131
PMCPMC9543342
OpenAlexW4283398838

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.