Evidence map›Paper›PMID 35748076›Full record

ArticleYonsei medical journal2022

Ovarian Tissue-Based Hormone Replacement Therapy Recovers Menopause-Related Signs in Mice.

Dahyeon Yoo, Nanum Chung, Jungyoung Yoo, Chae Young Song, Chungmo Yang, Hye Won Youm, Kangwon Lee, Jin Hyun Jun, Jaewang Lee, Jung Ryeol Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Yonsei medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Dahyeon YooDepartment of Biomedical Laboratory Science, Eulji University, Seongnam, Korea.ORCID https://orcid.org/0000-0002-4021-4498
Nanum ChungDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0001-9912-7615
Jungyoung YooDepartment of Biomedical Laboratory Science, Eulji University, Seongnam, Korea.ORCID https://orcid.org/0000-0001-6357-7569
Chae Young SongDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-7566-7454
Chungmo YangDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-4690-1061
Hye Won YoumDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-1735-7191
Kangwon LeeDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0001-5745-313X
Jin Hyun JunDepartment of Biomedical Laboratory Science, Eulji University, Seongnam, Korea.ORCID https://orcid.org/0000-0001-9898-4471
Jaewang LeeDepartment of Biomedical Laboratory Science, Eulji University, Seongnam, Korea. wangjaes@gmail.com.ORCID https://orcid.org/0000-0001-6801-7149
Jung Ryeol LeeDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0003-3743-2934
Seoul National University · KREulji University · KRSeoul National University Bundang Hospital · KR

Funding

Korea Health Industry Development Institute HI21C1353National Research Foundation of Korea NRF-2018R1D-1A1B07046419
6 · The paper itself

Abstract

purposeIn women, menopause manifests with a variety of symptoms related to sex-hormone deficiency. Supplementing steroid hormones with pharmacological drugs has been widely practiced. However, considering the possible complications associated with artificial hormone therapy, studies have been conducted to find an alternative to pharmacological hormone replacement therapy. Accordingly, this study aimed to evaluate the efficacy of tissue-based hormone replacement therapy (tHRT) for treating post-menopausal signs and symptoms. MATERIALS AND

methodsCD-1 mice were ovariectomized, and the ovaries were cryopreserved. Following artificial induction of post-menopausal osteoporosis, cryopreserved ovaries were subcutaneously autografted, and indexes related to bone health were monitored for 12 weeks. Bone mineral density (BMD), bone mineral contents (BMC), total bone volume (BV), and body fat mass were measured by dual energy X-ray absorptiometry. Uterine atrophy was assessed histologically, and bone microstructures were imaged by micro-computed tomography analysis.

resultsRegardless of the number of grafted ovaries, the BMC, BMD, and BV values of mice that underwent ovary transplantation were better than those that did not undergo transplantation. The uteruses in these mice were thicker and heavier after auto-transplantation. Furthermore, the bone microstructure recovered after tHRT.

conclusionRecovery of menopause-related bone loss and uterine atrophy was achieved through tHRT. Ovarian tissue cryopreservation and transplantation may be applicable not only in patients wanting to preserve fertility but also in sex hormone-deficient post-menopausal women.

Indexed as

Hormone Replacement TherapyMenopauseAbsorptiometry, PhotonAnimalsAtrophyBone DensityEstrogen Replacement TherapyFemaleHormonesHumansMiceX-Ray MicrotomographyHormonesbioimaging analysismenopauseovarian transplantationsymptomsTissue-based hormone replacement therapy

Identifiers

PMID35748076
PMCPMC9226832
OpenAlexW4283445993

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.