ArticleAnimal models and experimental medicine2022
Distinct neuronal excitability alterations of medial prefrontal cortex in early-life neglect model of rats.
Article in Animal models and experimental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- Network Analysis of Symptom-Level Interrelationships Between Adverse Childhood Experiences and Insomnia Symptoms in Adolescents: A Large-Sample Study.Nature and science of sleep · 2026Article
- Prefrontal parvalbumin interneurons mediate CRHR1-dependent early-life stress-induced cognitive deficits in adolescent male mice.Molecular psychiatry · 2025Article
- Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms.Animal models and experimental medicine · 2023Review
- Different coding characteristics between flight and freezing in dorsal periaqueductal gray of mice during exposure to innate threats.Animal models and experimental medicine · 2022Article
- Distinct neuronal excitability alterations of medial prefrontal cortex in early-life neglect model of rats.Animal models and experimental medicine · 2022Article
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6 authors at 1 institution in 1 country.
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Abstract
objectEarly-life neglect has irreversible emotional effects on the central nervous system. In this work, we aimed to elucidate distinct functional neural changes in medial prefrontal cortex (mPFC) of model rats.
methodsMaternal separation with early weaning was used as a rat model of early-life neglect. The excitation of glutamatergic and GABAergic neurons in rat mPFC was recorded and analyzed by whole-cell patch clamp.
resultsGlutamatergic and GABAergic neurons of mPFC were distinguished by typical electrophysiological properties. The excitation of mPFC glutamatergic neurons was significantly increased in male groups, while the excitation of mPFC GABAergic neurons was significant in both female and male groups, but mainly in terms of rest membrane potential and amplitude, respectively.
conclusionsGlutamatergic and GABAergic neurons in medial prefrontal cortex showed different excitability changes in a rat model of early-life neglect, which can contribute to distinct mechanisms for emotional and cognitive manifestations.
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