Evidence map›Paper›PMID 35747850›Full record

ArticleHemaSphere2022

Determinants and Clinical Significance of Musculoskeletal Symptoms in Patients With Chronic Graft-Versus-Host Disease.

Ana Zelic Kerep, Filip Pirsl, Seth Steinberg, Sandra Mitchell, Lauren Curtis, Noa Holtzman, Sencer Goklemez, Ervina Bilic, Edward Cowen, Dominique Pichard and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HemaSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00092235 (Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00092235 recruitingnot on this map

Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2004Enrolled650ConditionsChronic Graft vs. Host Disease
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 2 countries.

Ana Zelic KerepImmune Deficiency Cellular Therapy Program, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Filip PirslImmune Deficiency Cellular Therapy Program, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Seth SteinbergBiostatistics and Data Management Section, NCI, CCR, NIH, Bethesda, MD, USA.
Sandra MitchellOutcomes Research Branch, Division of Cancer Control and Population Sciences, CCR, NCI, NIH, Rockville, MD, USA.
Lauren CurtisImmune Deficiency Cellular Therapy Program, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Noa HoltzmanImmune Deficiency Cellular Therapy Program, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Sencer GoklemezImmune Deficiency Cellular Therapy Program, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Ervina BilicDepartment of Neurology, University Hospital Centre Zagreb, Croatia.
Edward CowenDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.
Dominique PichardDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.
Galen JoeRehabilitation Medicine Department, Clinical Center (CC), NIH, Bethesda, MD, USA.
Leora ComisRehabilitation Medicine Department, Clinical Center (CC), NIH, Bethesda, MD, USA.
Annie ImDivision of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ann BergerDepartment of Pain and Palliative Care, CC, NIH, Bethesda, MD, USA.
Laura Parsons-WandellImmune Deficiency Cellular Therapy Program, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Drazen PulanicDivision of Hematology, Department of Internal Medicine, University Hospital Center Zagreb, Croatia.
Kristin BairdPediatric Oncology Branch, CCR, NCI, NIH, Bethesda, MD, USA.
Ronald GressImmune Deficiency Cellular Therapy Program, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Steven PavleticImmune Deficiency Cellular Therapy Program, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Center for Cancer Research · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institutes of Health · USNational Institutes of Health Clinical Center · USUniversity Hospital Centre Zagreb · HRNational Cancer Institute · USUniversity of Pittsburgh Medical Center · USUniversity of Zagreb · HR

Funding

ETIB Clinical TrialsZIABC010960 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GRESS, RONALD · 2009 to 2023
$30.7M
ETIB Clinical Research CoreZIDBC010963 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GRESS, RONALD · 2009 to 2023
$28.6M
Chronic graft-versus-host diseaseZIAAR041227 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COWEN, EDWARD · 2022 to 2025
$1.4M
6 · The paper itself

Abstract

Musculoskeletal symptoms in chronic graft-versus-host disease (cGVHD) are rare manifestations contributing to disease burden. This study assesses the frequency of muscle cramps, joint and muscle aches, and muscle weakness in a cohort of patients severely affected by cGVHD. Three hundred thirty-four patients participated in the NCI natural history study of cGVHD (NCT00092235) from October 2004 to March 2017. Five-point Lee cGVHD Symptom Scale was dichotomized (less symptom bother-0, 1, 2; severe symptom bother-3, 4) and tested for associations with: Short Form 36 (SF36), 2-minute walk test, grip strength, joint range of motion, and human activity profile, clinical and laboratory data. Seventy-five point four percent of patients reported joint and muscle aches (36.8% severe, Lee Symptom Scale score 3-4), 74.3% muscle cramps (33.5% severe), and 82.34% muscle weakness (45.51% severe), which were associated with reduced functional capacity (SF36 Physical Component Scale,

Identifiers

PMID35747850
PMCPMC9208866
OpenAlexW3080377031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.