ArticleRSC advances2021
The colorimetric and microfluidic paper-based detection of cysteine and homocysteine using 1,5-diphenylcarbazide-capped silver nanoparticles.
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Mathematical processing of RGB data in microfluidic paper-based analytical devices.Scientific reports · 2024Article
- Signaling strategies of silver nanoparticles in optical and electrochemical biosensors: considering their potential for the point-of-care.Mikrochimica acta · 2023Review
- Near-Field Communication Tag for Colorimetric Glutathione Determination with a Paper-Based Microfluidic Device.Biosensors · 2023Article
- PMMA/paper hybrid microfluidic chip for simultaneous determination of arginine and valine in human plasma.Mikrochimica acta · 2022Article
- Waterproof Cellulose-Based Substrates for In-Drop Plasmonic Colorimetric Sensing of Volatiles: Application to Acid-Labile Sulfide Determination in Waters.ACS sensors · 2022Article
- Development of a Novel Benzimidazole-Based Probe and Portable Fluorimeter for the Detection of Cysteine in Human Urine.Biosensors · 2021Article
- An All-in-One Solid State Thin-Layer Potentiometric Sensor and Biosensor Based on Three-Dimensional Origami Paper Microfluidics.Biosensors · 2021Article
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Authors and funding
2 authors.
Funding
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Abstract
We have prepared a microfluidic paper-based analytical device (μPAD) for the determination of cysteine and homocysteine based on 1,5-diphenylcarbazide-capped silver nanoparticles. The μPAD was developed to identify and quantify the levels of cysteine and homocysteine. The proposed μPAD enabled the detection of cysteine and homocysteine using a colorimetric reaction based on modified silver nanoparticles. The color of the modified AgNPs in the test zone immediately changed after the addition of cysteine and homocysteine. Based on this change, the quantification of these two amino acids was achieved using an RGB color model and ImageJ software. Under optimized conditions, the proposed device enabled the determination of cysteine in the 0.20-20.0 μM concentration range with a limit of detection (LOD) of 0.16 μM. In addition, the LOD of homocysteine was calculated to be 0.25 μM with a linear range of 0.50-20.0 μM. In this work, we focused on the use of the μPAD for the analysis of a series of human urine samples.
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Registered trials
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