Evidence map›Paper›PMID 35747493›Full record

ArticleFrontiers in bioengineering and biotechnology2022

A Composite of Cubic Calcium-Magnesium Sulfate and Bioglass for Bone Repair.

Yan Chen, Tie Zhang, Qi Zhang, QingJian Lei, ShiJie Gao, KangWen Xiao, FeiFei Yan, Lin Cai

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Osteogenesis-synchronized degradation of MgBiomedical engineering online · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan ChenDepartment of Spine Surgery and Musculoskeletal Tumour, Zhongnan Hospital of Wuhan University, Wuhan, China.
Tie ZhangHubei Osteolink Biomaterial Co, Ltd. (Wuhan Hi-tech Research Center of Medical Tissues), Wuhan, China.
Qi ZhangHubei Osteolink Biomaterial Co, Ltd. (Wuhan Hi-tech Research Center of Medical Tissues), Wuhan, China.
QingJian LeiDepartment of Spine Surgery and Musculoskeletal Tumour, Zhongnan Hospital of Wuhan University, Wuhan, China.
ShiJie GaoDepartment of Spine Surgery and Musculoskeletal Tumour, Zhongnan Hospital of Wuhan University, Wuhan, China.
KangWen XiaoDepartment of Spine Surgery and Musculoskeletal Tumour, Zhongnan Hospital of Wuhan University, Wuhan, China.
FeiFei YanDepartment of Spine Surgery and Musculoskeletal Tumour, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lin CaiDepartment of Spine Surgery and Musculoskeletal Tumour, Zhongnan Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium sulfate (CS) bone cement has been shown to have good biocompatibility and can be used as a bone filler for repairing bone defects. However, its clinical application is limited due to its low compressive strength and weak bone repair activity. To this end, in this study, cubic crystalline magnesium-doped calcium sulfate (MgCS) was prepared and mixed with 45S5 bioglass (BG) to form a composite bone cement (MgCS/BG). The results show that cubic crystal calcium sulfate helps to increase the compressive strength of the composite bone cement to more than 60 MPa. More importantly, the obtained magnesium-doped composite bone cement can promote the adhesion and differentiation of mesenchymal stem cells and has good bioactivity. Through a skull defect model, it was found that MgCS/BG can significantly enhance bone defect repair and new bone formation. This new composite MgCS/BG is very promising for future translation into clinical applications.

Indexed as

bioglassbone reparationcalcium sulfatemagnesiumosteogenesis

Identifiers

PMID35747493
PMCPMC9209760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.