Evidence map›Paper›PMID 35747359›Full record

ArticleJournal of traditional and complementary medicine2022

Mechanism of action involved in the anxiolytic-like effects of Hibalactone isolated from

Matheus Gabriel de Oliveira, Lorrane Kelle da Silva Moreira, Larissa Cordova Turones, Dionys de Souza Almeida, Aline Nazareth Martins, Thiago Levi Silva Oliveira, Vinicius Barreto da Silva, Leonardo Luiz Borges, Elson Alves Costa, José Realino de Paula

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Gingerols and Shogaols ofJournal of experimental pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Matheus Gabriel de OliveiraFaculdade de Farmácia, Universidade Federal de Goiás, Av. Universitária com 1 Avenida s/n, Setor Universitário, 74605-220, Goiânia, Goiás, Brazil.
Lorrane Kelle da Silva MoreiraLaboratório de Farmacologia de Produtos Naturais e Sintéticos, Universidade Federal de Goiás, Avenida Esperança, s/n Campus Samambaia, 74690-900, Goiânia, Goiás, Brazil.
Larissa Cordova TuronesLaboratório de Farmacologia de Produtos Naturais e Sintéticos, Universidade Federal de Goiás, Avenida Esperança, s/n Campus Samambaia, 74690-900, Goiânia, Goiás, Brazil.
Dionys de Souza AlmeidaLaboratório de Farmacologia de Produtos Naturais e Sintéticos, Universidade Federal de Goiás, Avenida Esperança, s/n Campus Samambaia, 74690-900, Goiânia, Goiás, Brazil.
Aline Nazareth MartinsLaboratório de Farmacologia de Produtos Naturais e Sintéticos, Universidade Federal de Goiás, Avenida Esperança, s/n Campus Samambaia, 74690-900, Goiânia, Goiás, Brazil.
Thiago Levi Silva OliveiraFaculdade de Farmácia, Universidade Federal de Goiás, Av. Universitária com 1 Avenida s/n, Setor Universitário, 74605-220, Goiânia, Goiás, Brazil.
Vinicius Barreto da SilvaEscola de Ciências Médicas e da Vida, Pontifícia Universidade Católica de Goiás, Avenida Universitária 1.440, Setor Leste Universitário, 74605-010, Goiânia, Goiás, Brazil.
Leonardo Luiz BorgesEscola de Ciências Médicas e da Vida, Pontifícia Universidade Católica de Goiás, Avenida Universitária 1.440, Setor Leste Universitário, 74605-010, Goiânia, Goiás, Brazil.
Elson Alves CostaLaboratório de Farmacologia de Produtos Naturais e Sintéticos, Universidade Federal de Goiás, Avenida Esperança, s/n Campus Samambaia, 74690-900, Goiânia, Goiás, Brazil.
José Realino de PaulaFaculdade de Farmácia, Universidade Federal de Goiás, Av. Universitária com 1 Avenida s/n, Setor Universitário, 74605-220, Goiânia, Goiás, Brazil.
Universidade Federal de Goiás · BRPontifícia Universidade Católica de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Hibalactone (HB) is a lignan related to the anxiolytic-like effects of Experimental procedure: The effects of HB in mice were evaluated on light-dark box (LDB) and elevated plus maze (EPM) tests. The participation of 5-HT Results: Oral treatment with HB at a dose of 33 mg/kg showed an anxiolytic-like effect in the LDB and EPM tests. Besides that, the treatment altered the ethological parameters, frequency of head dips, and stretched-attend postures (SAP), important to better describe the anxiolytic profile of HB. Pretreatment with flumazenil (2 mg/kg) reverted the anxiolytic-like effect of HB on LDB and EPM tests. On the other hand, pretreatment with NAN-190 (0.5 mg/kg) not reverted the activity observed. Conclusion: Together, the results presented herein suggest that activation of the benzodiazepine site of the GABA

Indexed as

Benzodiazepine siteGABAA receptorMedicinal plantsMolecular dockingPharmacophore model

Identifiers

PMID35747359
PMCPMC9209824
OpenAlexW3199699424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.