Evidence map›Paper›PMID 35747354›Full record

ArticleJournal of traditional and complementary medicine2022

Protective effects of Thai

Pannawat Choowong-In, Jintana Sattayasai, Preecha Boonchoong, Chanasorn Poodendaen, Alexander Th Wu, Nareelak Tangsrisakda, Tarinee Sawatpanich, Supatcharee Arun, Nongnut Uabundit, Sitthichai Iamsaard

Open access · diamondAbstract read
In one paragraph

Article in Journal of traditional and complementary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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  8. Protective Effects ofLife (Basel, Switzerland) · 2025
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  9. Antihypertensive Effects of Lotus Seed (Pharmaceuticals (Basel, Switzerland) · 2025
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  10. Lotus seed (Journal of traditional and complementary medicine · 2025
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  11. Article
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  13. Neurology international · 2024
    Review
  14. Article
  15. Frontiers in neuroscience · 2024
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  16. Prevention of seminal vesicle damage byPharmaceutical biology · 2023
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  17. Seed extract of ThaiPharmaceutical biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Pannawat Choowong-InDepartment of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Jintana SattayasaiDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Preecha BoonchoongDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Warinchamrab, Ubon Ratchathani, 34190, Thailand.
Chanasorn PoodendaenDepartment of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Alexander Th WuInternational Ph.D. Program for Translational Science, College of Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan.
Nareelak TangsrisakdaDepartment of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Tarinee SawatpanichDepartment of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Supatcharee ArunDepartment of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Nongnut UabunditDepartment of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Sitthichai IamsaardDepartment of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Khon Kaen University · THNaresuan University · THTaipei Medical University Hospital · TWUbon Ratchathani University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: Chronic stress is a major common cause of male infertility. Many species of velvet beans are shown to be rich in l-DOPA. In Thai folklore medicine, seeds of Experimental procedure: Mice were divided into 4 groups: (I) control, (II) CUMS, (III) T-MP300 + CUMS, and (IV) T-MP600 + CUMS. Groups I and II received DW while groups III and IV were pretreated with the seed extracts (300 and 600 mg/kg BW) for 14 consecutive days before co-treatment with a randomly different CUMS/day (from 12 mild stressors) for 43 days. Results and conclusion: T-MP seed extract contained l-DOPA approximately 10% of total dried weight. A dose of 600 mg/kg improved sexual performances and degenerative seminiferous epithelium in CUMS mice. Sperm qualities and testosterone level were elevated while corticosterone was decreased in co-treatment groups. T-MP-CUMS cotreated groups also improved expressions of AKAP4, AR, and TyrPho proteins in testis, epididymis, and sperm. T-MP increased StAR and CYP11A1 expressions in testis. It also suppressed testicular apoptosis via decreased expressions of Hsp70, caspases 3, and 9. T-MP seeds containing l-DOPA could improve sexual behaviors and essential reproductive proteins caused by CUMS. Section: Natural Products. Taxonomy classification by evise: Traditional Herbal Medicine; Animal Model; Histopathology.

Indexed as

AKAP4CUMSl-DOPAT-MPTyrPho

Identifiers

PMID35747354
PMCPMC9209868
OpenAlexW4200105592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.