Evidence map›Paper›PMID 35747350›Full record

ArticleJournal of traditional and complementary medicine2022

Wahyu Widowati, Sijani Prahastuti, Meilinah Hidayat, Stella Tinia Hasianna, Roro Wahyudianingsih, The Fransiska Eltania, Alya Mardhotillah Azizah, Jenifer Kiem Aviani, Mawar Subangkit, Rr Anisa Siwianti Handayani and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of traditional and complementary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Hepatoprotective effects ofIranian journal of basic medical sciences · 2025
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  3. Article
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  5. Brazilin cream fromPeerJ · 2024
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  6. Review
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  8. Protective effect of yacon leaves extract (Research in pharmaceutical sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Wahyu WidowatiFaculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia.
Sijani PrahastutiFaculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia.
Meilinah HidayatFaculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia.
Stella Tinia HasiannaFaculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia.
Roro WahyudianingsihFaculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia.
The Fransiska EltaniaFaculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri 65, Bandung, 40164, West Java, Indonesia.
Alya Mardhotillah AzizahAretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia.
Jenifer Kiem AvianiAretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia.
Mawar SubangkitLaboratory of Veterinary Pathology, Faculty of Veterinary Medicine, IPB University, Jl. Agathis No. 1, IPB University Darmaga Campus, Bogor, 16680, West Java, Indonesia.
Rr Anisa Siwianti HandayaniAretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia.
Hanna Sari Widya KusumaAretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk II No. 9, Bandung, 40163, West Java, Indonesia.
Maranatha Christian University · IDIPB University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Cis-Diamminedichloroplatinum (II) (Cisplatin) is one of the most synthetic anticancer drug but have several adverse effects and one of them is acute ren failure. Cisplatin can induce nephrotoxicity occur via the toxic generation of reactive oxygen species (ROS). Black soybean ( Experimental procedure: Cisplatin-induced nephrotoxicity rats treated with EEBS and the blood samples taken on days 0, 9, and 18. The effects of EEBS was evaluated by determining Interferon-γ (IFN-γ), Caspase-3 (Casp-3), and Interleukin-1β (IL-1β) expression using immunohistochemistry (IHC), blood urea nitrogen (BUN), Uric Acid (UA) content and catalase (CAT) content in the blood plasma with colorimetric assay kit. Results and conclusion: Based on the results, EEBS treatment had successfully reduced pro-inflammatory cytokines IL-1β and IFN-γ, and improved physiological condition by lowering BUN and UA content while increasing CAT activity. No significant effect was found in Casp-3 expression. EEBS has potential to improve acute renal failure condition through inflammatory suppression and renal function improvement.

Indexed as

Blood urea nitrogenCatalaseFibronectinGlycine max L. Merr.Nephrotoxicity

Identifiers

PMID35747350
PMCPMC9209860
OpenAlexW4205159851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.