Evidence map›Paper›PMID 35747333›Full record

ArticleInfection and drug resistance2022

A New Variant of Mutational and Polymorphic Signatures in the

Arome Solomon Odiba, Olanrewaju Ayodeji Durojaye, Ifeoma Maureen Ezeonu, Anthony Christian Mgbeahuruike, Bennett Chima Nwanguma

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Mechanism of azole resistance inJournal of medical microbiology · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Prevalence and drug susceptibility of clinicalOne health (Amsterdam, Netherlands) · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Arome Solomon OdibaDepartment of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, 410001, Nigeria.ORCID 0000-0001-9581-0724
Olanrewaju Ayodeji DurojayeDepartment of Chemical Sciences, Coal City University, Emene, Enugu State, Nigeria.ORCID 0000-0001-8988-8154
Ifeoma Maureen EzeonuDepartment of Microbiology, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, 410001, Nigeria.ORCID 0000-0001-6758-2066
Anthony Christian MgbeahuruikeDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, 410001, Nigeria.ORCID 0000-0001-7426-8032
Bennett Chima NwangumaDepartment of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, 410001, Nigeria.ORCID 0000-0002-8687-7449
University of Nigeria · NGUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Resistance to antifungal drugs for treating Materials and Methods: Classical methods were employed to characterize clinical isolates sampled from women and dogs of reproductive age. For fluconazole efficacy studies, CLSI guidelines on drug susceptibility testing were used. To understand the susceptibility pattern, various molecular and structural analytic approaches, including sequencing, in silico site-directed mutagenesis, and protein-ligand profiling, were applied to the Results: The following Conclusion: Taken together, our results showed new mutations in the heme-binding pocket of caCYP51 that explain the resistance to fluconazole exhibited by the

Indexed as

Candida infectionCYP51drug resistanceERG11fluconazolemutation

Identifiers

PMID35747333
PMCPMC9213107
OpenAlexW4282959410

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.