ArticlePlastic and reconstructive surgery. Global open2022
Treatment of Delayed-onset Inflammatory Reactions to Hyaluronic Acid Filler: An Algorithmic Approach.
Article in Plastic and reconstructive surgery. Global open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Effectiveness and Safety of RHA3 vs a Comparator Product for Lip Augmentation: A Randomized, Controlled, Prospective, Multicenter Clinical Study.Aesthetic surgery journal · 2025Trial
- Review
- The Management of Poly-L-Lactic Acid (PLLA) Nodules: A Scoping Review and Evidence-Mapped Clinical Pathway.Cureus · 2026Review
- Clinical safety of a low-modification hyaluronic acid filler (MoD 2%) for facial rejuvenation.JPRAS open · 2026Article
- Exploring the Immunological Implications of Insoluble Particulate Impurities in Hyaluronic Acid Fillers: Integrated Physicochemical and Histological Analyses of the Cohesive Polydensified Matrix Range.Clinical, cosmetic and investigational dermatology · 2026Article
- Incidence and Characteristics of Delayed Inflammatory Reactions Secondary to Hyaluronic Acid Filler Injections: A Systematic Review With Meta-Analysis.Aesthetic surgery journal. Open forum · 2026Review
- Intraoral Surgical Approach and Evaluation of the Cellular Profile in a Granulomatous Reaction to a Foreign Body Induced by Calcium Hydroxyapatite in the Facial Region: A Case Report.Journal of cosmetic dermatology · 2026Article
- Impact of Hyaluronic Acid Lip Filling on the Electromyographic Activity of the Orbicularis Oris Muscle in Adult Women.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2025Article
- The Immunologic Spectrum of Biostimulators and Its Clinical Importance.Plastic and reconstructive surgery. Global open · 2025Article
- Reduction of Early-Onset Calcium Hydroxylapatite-Carboxymethylcellulose Accumulations Using Focused Mechanical Vibration: An Experimental Model and Case Report.Journal of cosmetic dermatology · 2025Article
- Long-term management of recurrent biofilms in the tear trough regions following hyaluronic acid filler treatment.JAAD case reports · 2025Article
- Exuberant delayed granulomatous reaction to hyaluronic acid filler material.Journal of surgical case reports · 2025Article
- Management of Delayed Complications of Hyaluronic Acid Fillers: Case Series From the Middle East.Journal of cosmetic dermatology · 2025Article
- Safety and Performance of RHA4 in the Midface Using the Multilayering Technique: Preclinical and Clinical Evidence.Plastic and reconstructive surgery. Global open · 2025Article
- Review
- Mussel-inspired sulfated hyaluronan cryogel patch with antioxidant, anti-inflammatory, and drug-loading properties for multifunctional wound adhesives.Bioactive materials · 2024Article
- A Structured Approach for Treating Calcium Hydroxylapatite Focal Accumulations.Aesthetic surgery journal · 2024Review
- Late-Onset Reactions after Hyaluronic Acid Dermal Fillers: A Consensus Recommendation on Etiology, Prevention and Management.Dermatology and therapy · 2024Review
- Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine?International journal of molecular sciences · 2024Review
- Ultrasound-guided Treatment of Polycaprolactone Granuloma.Plastic and reconstructive surgery. Global open · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid fillers are one of the most widely used and versatile fillers worldwide. Although traditionally regarded as immunologically inert, many currently available products have been substantially modified to improve longevity and to optimize properties for specific indications. Such modifications, either alone or in combination with other factors (such as the immune status of the patient, immune-triggering events, and bacterial contamination), may lead to the development of late-onset inflammatory nodules in some patients. This article discusses the clinical presentation of late-onset adverse inflammatory reactions to hyaluronic acid injections, describes their likely triggers, and presents the author's treatment algorithm for successful resolution.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.