ArticleNature cardiovascular research2022
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease.
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Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Myocardial Immune Cells: The Basis of Cardiac Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023Pooled it
- Spatially Distinct Bone Marrow Sites Are Asymmetrically Impacted by Inflammatory Cardiovascular Disease.JACC. Basic to translational science · 2026Article
- The Bone Marrow's Division of Labor in Cardiovascular Disease: A Scattered Organ Comes Into Focus.JACC. Basic to translational science · 2026Article
- The Role and Mechanism of Endothelial Progenitor Cell-Derived Extracellular Vesicles in Vascular Repair of Ischemic Heart Disease.Journal of cardiovascular translational research · 2026Review
- Universal catalytic endothelial lineage nanovesicles for targeting and rescuing ischemic endothelium.Cell reports. Medicine · 2026Article
- Endothelial cells modulate immune cell responses during atherosclerosis.Trends in immunology · 2026Review
- The Immune System as a Proarrhythmic Mediator: A Novel Paradigm for the Development of New Antiarrhythmic Therapy.The Canadian journal of cardiology · 2026Review
- Neutrophil-Derived Oncostatin M Contributes to Endothelial Cell Dysfunction DuringbioRxiv : the preprint server for biology · 2026Article
- Crosstalk between bone and vasculature within bone.Fundamental research · 2026Review
- Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell-Based Therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Non-invasive detection of bone marrow fibrosis in myeloproliferative neoplasms using cell-free RNA.iScience · 2026Article
- The role of vascular aging, bone marrow and immune system in hypertension.Cell death discovery · 2026Review
- Vascular Cognitive Impairment and Dementia: Clinical Features, Neuropathology, and Biomarkers.Journal of the American College of Cardiology · 2026Review
- Piezo1 Upregulation in Monocyte-Derived Macrophages Impairs Post-Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neutrophil-derived oncostatin m contributes to endothelial cell dysfunction during Treponema denticola interaction.PloS one · 2026Article
- Circulating Plasma Proteins Influence the Risk of Aortic Dissection via Blood Pressure: A Network Mendelian Randomization and Multi-Omics Study.Journal of inflammation research · 2026Article
- The neuroimmune axis in cardiovascular disease: from immune activation to inflammatory resolution.Frontiers in immunology · 2026Review
- The effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial.Frontiers in nutrition · 2026Article
- Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease.Comprehensive Physiology · 2025Review
- Altered thrombopoiesis in spontaneously hypertensive rats.Scientific reports · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors at 10 institutions in 7 countries.
David RohdeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3785-9375
Katrien VandoorneCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
I-Hsiu LeeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7200-7867
Jana GruneCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Shuang ZhangCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5570-5954
Cameron S McAlpineCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Maximilian J SchlossCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ribhu NayarCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Gabriel CourtiesCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Vanessa FrodermannCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5566-6692
Gregory WojtkiewiczCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3148-8411
Lisa HonoldCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Qi ChenMax Planck Institute for Molecular Biomedicine, Muenster, Germany.ORCID 0000-0001-8485-6540
Stephen SchmidtCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yoshiko IwamotoCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Yuan SunCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sebastian CremerCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Friedrich F HoyerCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Oriol Iborra-EgeaInstitut del Cor Germans Trias i Pujol, Barcelona, Spain.ORCID 0000-0002-7280-859X
Christian Muñoz-GuijosaInstitut del Cor Germans Trias i Pujol, Barcelona, Spain.
Fei JiDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Bin ZhouState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0001-5278-5522
Ralf H AdamsMax Planck Institute for Molecular Biomedicine, Muenster, Germany.ORCID 0000-0003-3031-7677
Joshua D WytheCardiovascular Research Institute, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Juan HidalgoInstitute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Barcelona, Spain.ORCID 0000-0003-0921-1122
Hideto WatanabeInstitute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan.
Yookyung JungWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Anja M van der LaanHeart Center, Department of Cardiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Jan J PiekHeart Center, Department of Cardiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Youmna KfouryCenter for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA, USA.
Pauline A DésogèreMartinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Claudio VinegoniCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9818-3639
Partha DuttaPittsburgh Heart, Lung, Blood and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Peter CaravanMartinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0002-3179-6537
Antoni Bayes-GenisInstitut del Cor Germans Trias i Pujol, Barcelona, Spain.
Peter LibbyDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1502-502X
David T ScaddenCenter for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA, USA.
Charles P LinCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kamila NaxerovaCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Filip K SwirskiCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3163-9152
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4021-1887
Harvard University · USInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESAmsterdam University Medical Centers · NLMax Planck Institute for Molecular Biomedicine · DEAichi Medical University · JPBaylor College of Medicine · USBrigham and Women's Hospital · USChinese Academy of Sciences · CNUniversitat Autònoma de Barcelona · ESUniversity of Pittsburgh · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Takara Leah Stanley · 1994 to 2026
$31.6MTranslational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Zahi A. Fayad · 2017 to 2026
$24.3MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MImaging organ system interfaces in ischemic heart diseaseR35HL139598 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2018 to 2024
$6.9MMacrophages in homeostasis and cardiovascular diseaseR35HL135752 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SWIRSKI, FILIP K · 2017 to 2023
$5.4MSkeletal Phenotyping CoreP30AR066261 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI KRONENBERG, HENRY M. · 2014 to 2018
$3.5MSkull marrow crosstalk with the central nervous systemR01NS108419 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSKOWITZ, MICHAEL A., NAHRENDORF, MATTHIAS · 2018 to 2022
$3.4MLifestyle effects on hematopoiesis and atherosclerosisR01HL128264 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, SWIRSKI, FILIP K · 2015 to 2018
$3.3MQuantitative nanoparticle imaging of macrophagesR01HL131495 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, WEISSLEDER, MD, PHD, RALPH · 2017 to 2020
$2.7MInterfering with the macrophage life cycle of atherosclerosisR01HL125428 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, DANIEL G, NAHRENDORF, MATTHIAS · 2017 to 2020
$1.9MNHLBI NIH HHS P01 HL131478NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R01 HL125428NHLBI NIH HHS R01 HL128264NHLBI NIH HHS R01 HL131495NHLBI NIH HHS R35 HL135752NHLBI NIH HHS R35 HL139598NIAMS NIH HHS P30 AR066261NIDDK NIH HHS P30 DK040561NINDS NIH HHS R01 NS108419
Abstract
Abnormal hematopoiesis advances cardiovascular disease by generating excess inflammatory leukocytes that attack the arteries and the heart. The bone marrow niche regulates hematopoietic stem cell proliferation and hence the systemic leukocyte pool, but whether cardiovascular disease affects the hematopoietic organ's microvasculature is unknown. Here we show that hypertension, atherosclerosis and myocardial infarction (MI) instigate endothelial dysfunction, leakage, vascular fibrosis and angiogenesis in the bone marrow, altogether leading to overproduction of inflammatory myeloid cells and systemic leukocytosis. Limiting angiogenesis with endothelial deletion of
Indexed as
HematopoiesisMyeloid CellsVascular Endothelial Growth Factor Receptor-2AnimalsAtherosclerosisCell ProliferationDisease Models, AnimalEndothelial CellsFemaleHumansHypertensionInterleukin-6LeukocytosisMaleMiceMice, Inbred C57BLInterleukin-6Kdr protein, mouseVascular Endothelial Growth Factor Receptor-2Versicans
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.