Evidence map›Paper›PMID 35747092›Full record

ArticleClinical kidney journal2022

Association of obesity with 3-month mortality in kidney failure patients with COVID-19.

Ekamol Tantisattamo, Celine Imhof, Kitty J Jager, Luuk B Hilbrands, Rebecca Guidotti, Mahmud Islam, Dajana Katicic, Constantijn Konings, Femke M Molenaar, Ionut Nistor and 8 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 6 countries.

Ekamol TantisattamoHarold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine School of Medicine, Orange, CA, USA.ORCID https://orcid.org/0000-0003-0883-6892
Celine ImhofDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Kitty J JagerERA Registry, Department of Medical Informatics, Amsterdam University Medical Center, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Luuk B HilbrandsDepartment of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-4935-9765
Rebecca GuidottiInstitute of Nephrology, City Hospital Waid and Triemli, Zurich, Switzerland.
Mahmud IslamZonguldak Ataturk state hospital, Zonguldak, Turkey.ORCID https://orcid.org/0000-0003-1284-916X
Dajana KaticicCroatian Society of Nephrology, Dialysis and Transplantation, Croatia.
Constantijn KoningsCatharina Ziekenhuis, Eindhoven, The Netherlands.
Femke M MolenaarUniversity Medical Center Utrecht, Utrecht, The Netherlands.
Ionut NistorFaculty of Medicine, University of Medicine and Pharmacy, Grigore T.Popa, Iași, Romania.
Marlies NoordzijDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
María Luisa Rodríguez FerreroDepartment of Nephrology, Hospital General Universitario Gregorio Marañon, Madrid, Spain.
Martine A M VerhoevenFranciscus Gashuis & Vlietalnd, Schiedam, The Netherlands.
Aiko P J de VriesLeiden University Medical Center, Leiden, The Netherlands.
Kamyar Kalantar-ZadehHarold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine School of Medicine, Orange, CA, USA.ORCID https://orcid.org/0000-0002-8666-0725
Ron T GansevoortDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Priya VartDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
ERACODA collaborators
University Medical Center Groningen · NLFranciscus Vlietland · NLHospital General Universitario Gregorio Marañón · ESLeiden University Medical Center · NLRadboud University Nijmegen · NLUniversity of California, Irvine · USBülent Ecevit University · TRGrigore T. Popa University of Medicine and Pharmacy · ROTriemli Hospital · CHUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In the general population with coronavirus disease 2019 (COVID-19), obesity is associated with an increased risk of mortality. Given the typically observed obesity paradox among patients on kidney function replacement therapy (KFRT), especially dialysis patients, we examined the association of obesity with mortality among dialysis patients or living with a kidney transplant with COVID-19. Methods: Data from the European Renal Association COVID-19 Database (ERACODA) were used. KFRT patients diagnosed with COVID-19 between 1 February 2020 and 31 January 2021 were included. The association of Quetelet's body mass index (BMI) (kg/m Results: In 3160 patients on KFRT (mean age: 65 years, male: 61%), 99 patients were lean, 1151 normal weight (reference), 1160 overweight, 525 obese I and 225 obese II/III. During follow-up of 3 months, 28, 20, 21, 23 and 27% of patients died in these categories, respectively. In the fully adjusted model, the hazard ratios (HRs) for 3-month mortality were 1.65 [95% confidence interval (CI): 1.10, 2.47], 1 (ref.), 1.07 (95% CI: 0.89, 1.28), 1.17 (95% CI: 0.93, 1.46) and 1.71 (95% CI: 1.27, 2.30), respectively. Results were similar among dialysis patients ( Conclusion: In KFRT patients with COVID-19, on dialysis or a kidney transplant, obesity is associated with an increased risk of mortality at 3 months. This is in contrast to the obesity paradox generally observed in dialysis patients. Additional studies are required to corroborate the sex difference in the association of obesity with mortality.

Indexed as

COVID-19kidney failuremortalityobesity paradoxreverse epidemiology

Identifiers

PMID35747092
PMCPMC8992331
OpenAlexW4225716700

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.