ArticleNewborn (Clarksville, Md.)
Current Understanding of Transfusion-associated Necrotizing Enterocolitis: Review of Clinical and Experimental Studies and a Call for More Definitive Evidence.
Article in Newborn (Clarksville, Md.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association of anemia and necrotizing enterocolitis in neonates: Systematic review and meta-analysis of transfusion thresholds, erythropoietin trials, and observational studies.Journal of neonatal-perinatal medicine · 2026Pooled it
- Necrotizing Enterocolitis in Infants with Hybrid Stage 1 Palliation is Common and Difficult to Predict.Pediatric cardiology · 2026Article
- Necrotizing Enterocolitis in Term Neonates with Critical Congenital Heart Disease: Associated Risk Factors and Clinical Outcomes.Journal of cardiovascular development and disease · 2026Article
- Emerging evidence on the safety of enteral feeding during PRBC transfusion in preterm infants.Pediatric research · 2026Article
- Designing and implementing a clinical decision support tool to improve compliance with NICU transfusions.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Surgical Necrotising Enterocolitis (S-NEC): Where We Stand Today: A Narrative Review.Journal of clinical medicine · 2026Review
- Anemia and Transfusion in Preclinical Models of Neonatology.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Comparison of Necrotizing Enterocolitis After Surgical Norwood versus Hybrid Stage 1 Palliation.Pediatric cardiology · 2025Article
- Variability in the Deformability of Red Blood Cells: Application to Treating Premature Newborns with Blood Transfusion.International journal of molecular sciences · 2025Article
- Association of timing of initial breastfeeding and neonatal outcome in very preterm infants: a multicentre cohort study in China.BMJ paediatrics open · 2025Observational
- Banked term umbilical cord blood to meet the packed red blood cell transfusion needs of extremely-low-gestational-age neonates: a feasibility analysis.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Transfusion-associated necrotising enterocolitis in very low birth weight babies: transfusion and feeding practices in two neonatal units in Bloemfontein, Free State.The Southern African journal of critical care : the official journal of the Critical Care Society · 2024Article
- Clinical Dilemma Involving Treatments for Very Low-Birth-Weight Infants and the Potential Risk of Necrotizing Enterocolitis: A Narrative Literature Review.Journal of clinical medicine · 2023Review
- New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application.Frontiers in immunology · 2023Review
- State-of-the-art review and update ofFrontiers in pediatrics · 2023Review
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 7 countries.
Funding
Abstract
Introduction: The association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC), so-called transfusion-associated NEC (ta-NEC), was first described in 1987. However, further work is needed to confirm a causal relationship, elucidate underlying mechanisms, and develop possible strategies for prevention. We performed an extensive literature search in the databases PubMed, EMBASE, and Scopus. Areas covered: Although multiple retrospective human studies have strongly suggested an association between blood transfusions and subsequent occurrence of NEC, meta-analyses of randomized controlled trials (RCTs) testing RBC transfusion thresholds or the use of recombinant erythropoiesis-stimulating growth factors did not confirm an association of anemia with ta-NEC. These conflicting data necessitated the development of an animal model to elucidate mechanisms and causal factors. Data from this recent mouse model of ta-NEC highlighted the importance of sequential exposure to severe anemia followed by transfusion for development of ta-NEC. Expert opinion: This review summarizes current human and experimental data, highlights open questions, and suggests avenues for further research aimed at preventing ta-NEC in preterm infants. Further studies are required to delineate whether there is a tipping point, in terms of the level and duration of anemia, and to develop an effective strategy for blood management and the quality of RBC transfusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.