ArticleInternational journal of chronic obstructive pulmonary disease2022
Triglyceride-Glucose Index is a Risk Marker of Incident COPD Events in Women.
Article in International journal of chronic obstructive pulmonary disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Association of triglyceride-glucose index and triglyceride-glucose body mass index with risk and prognosis of chronic obstructive pulmonary disease: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- Association of triglyceride-glucose index with presence and development of impaired spirometry: results from Austrian LEAD cohort.BMC pulmonary medicine · 2026Article
- The relationship between triglyceride-glucose index and chronic lung diseases: a nationwide cohort study.BMC pulmonary medicine · 2026Article
- Triglyceride-glucose index and the progression of chronic obstructive pulmonary disease, panvascular disease, and multimorbidity: a prospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Association of C-Reactive Protein-Triglyceride Glucose Index With Chronic Obstructive Pulmonary Disease: Results From the NHANES and CHARLS Cohorts.Mediators of inflammation · 2026Article
- Dietary and lifestyle oxidative balance, metabolic dysfunction, and preserved ratio impaired spirometry in Chinese adults: a hospital-based cross-sectional study.Frontiers in nutrition · 2026Article
- A Nomogram for Predicting 5-Year Risk of New-Onset Type 2 Diabetes in Patients with COPD: A Two-Center Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Association of triglyceride-glucose related indices with all-cause and cardiovascular mortality in patients with chronic obstructive pulmonary disease: a large prospective cohort study.Nutrition journal · 2025Article
- The joint effect of triglyceride-glucose index and C-reactive protein levels on the risk of chronic obstructive pulmonary disease: a prospective cohort study.Lipids in health and disease · 2025Article
- Association of triglyceride glucose and obesity indices with chronic obstructive pulmonary disease in US adults: data from 2013 to 2018 NHANES.BMC pulmonary medicine · 2025Article
- Cigarette Smoking-Induced Glucose Metabolic Reprogramming in Chronic Obstructive Pulmonary Disease: Mechanisms and Therapeutic Implications.International journal of chronic obstructive pulmonary disease · 2025Review
- Triglyceride-glucose index as an independent predictor of mortality in patients with chronic respiratory diseases.Frontiers in pharmacology · 2025Article
- Association between metabolic syndrome and chronic obstructive pulmonary disease development in young individuals: a nationwide cohort study.Respiratory research · 2024Article
- Genetic association of lipids and lipid lowering drug target genes with sarcoidosis.Scientific reports · 2024Article
- Association between triglyceride-glucose index and sarcopenia in patients with chronic inflammatory airway disease.Heliyon · 2024Article
- Relationship between triglyceride-glucose index and blood eosinophils among asthmatic individuals in the USA.Lipids in health and disease · 2024Article
- The triglycerides and glucose index is more strongly associated with metabolically healthy obesity phenotype than the lipid and obesity indices.Journal of endocrinological investigation · 2024Article
- Effects of Low-Carbohydrate and Low-Fat Diets on Morbidity and Mortality of COPD.International journal of chronic obstructive pulmonary disease · 2024Article
- Exploring Gender Differences in the Association Between TyG Index and COPD: A Cross-Sectional Study from NHANES 1999-2018.International journal of chronic obstructive pulmonary disease · 2024Article
- Elevated Triglyceride-Glucose (TyG) Index Predicts Poor Clinical Outcomes in Critically Ill AECOPD Patients: A Retrospective Study.International journal of chronic obstructive pulmonary disease · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The triglyceride-glucose index (TyG index) is a marker of insulin resistance and metabolic dysfunction and has the advantage of being universally available. Although recent evidence suggests the TyG index has relevance to respiratory health, there have been no prospective studies assessing its value as a biomarker for chronic lung diseases. We aim to assess the TyG index as a potential risk marker for future incident COPD events in the general population. Patients and Methods: Baseline TyG index was assessed in 28,282 middle-aged men and women without previous history of chronic obstructive pulmonary disease (COPD) from the Malmö Preventive Project (men between 1974 and 1982 and women between 1982 and 1992). All subjects were followed up prospectively, and Cox proportional hazards regression was used to assess incident COPD events according to quartiles of TyG index. Results: After an average of 31 years of follow-up, TyG index was a strong predictor of future COPD events even after adjusting for potential confounders (Q4 (highest TyG index) HR (95% CI): 1.21 (1.09-1.35) vs Q1 (reference), p-trend <0.001). After stratifying by sex, the results remained statistically significant in women only (Q4 vs Q1 HR 1.72 (1.41-2.09)). Additionally, the risk remained significant in a cohort of life-long never smokers (Q4 vs Q1 HR 1.47 (1.08-2.01)). Conclusion: A raised TyG index is a novel risk marker of future incident COPD events in women. Insulin resistance as reflected by the TyG index can precede the development of obstructive lung disease and as such may be an easily measurable and useful predictor of COPD in women.
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