Evidence map›Paper›PMID 35746774›Full record

ArticleViruses2022

Evaluation of Screening Program and Phylogenetic Analysis of SARS-CoV-2 Infections among Hospital Healthcare Workers in Liège, Belgium.

Majdouline El Moussaoui, Nathalie Maes, Samuel L Hong, Nicolas Lambert, Stéphanie Gofflot, Patricia Dellot, Yasmine Belhadj, Pascale Huynen, Marie-Pierre Hayette, Cécile Meex and 13 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

Majdouline El MoussaouiDepartment of Infectious Diseases and General Internal Medicine, University Hospital of Liège, 4000 Liege, Belgium.ORCID 0000-0003-2560-5199
Nathalie MaesDepartment of Biostatistics and Medico-Economic Information, University Hospital of Liège, 4000 Liege, Belgium.ORCID 0000-0003-2552-2422
Samuel L HongDepartment of Microbiology, Immunology and Transplantation, Rega Institute, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-6354-4943
Nicolas LambertDepartment of Neurology, University Hospital of Liège, 4000 Liege, Belgium.
Stéphanie GofflotDepartment of Biothèque Hospitalo-Universitaire de Liège (BHUL), University Hospital of Liège, 4000 Liege, Belgium.
Patricia DellotDepartment of Infectious Diseases and General Internal Medicine, University Hospital of Liège, 4000 Liege, Belgium.
Yasmine BelhadjDepartment of Infectious Diseases and General Internal Medicine, University Hospital of Liège, 4000 Liege, Belgium.ORCID 0000-0002-2040-1309
Pascale HuynenDepartment of Clinical Microbiology, University Hospital of Liège, 4000 Liege, Belgium.
Marie-Pierre HayetteDepartment of Clinical Microbiology, University Hospital of Liège, 4000 Liege, Belgium.ORCID 0000-0002-9025-6493
Cécile MeexDepartment of Clinical Microbiology, University Hospital of Liège, 4000 Liege, Belgium.
Sébastien BontemsDepartment of Clinical Microbiology, University Hospital of Liège, 4000 Liege, Belgium.
Justine DefêcheDepartment of Clinical Microbiology, University Hospital of Liège, 4000 Liege, Belgium.
Lode GodderisCentre for Environment and Health, Department of Public Health and Primary Care, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-4764-8835
Geert MolenberghsInstitute for Biostatistics and Statistical Bioinformatics, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Christelle MeurisDepartment of Infectious Diseases and General Internal Medicine, University Hospital of Liège, 4000 Liege, Belgium.
Maria ArtesiLaboratory of Human Genetics, GIGA-Institute, University of Liège, 4000 Liege, Belgium.
Keith DurkinLaboratory of Human Genetics, GIGA-Institute, University of Liège, 4000 Liege, Belgium.
Souad RahmouniLaboratory of Animal Genomics, GIGA-Medical Genomics, GIGA-Institute, University of Liège, 4000 Liege, Belgium.
Céline GrégoireDepartment of Haematology, University Hospital of Liège, 4000 Liege, Belgium.
Yves BeguinDepartment of Haematology, University Hospital of Liège, 4000 Liege, Belgium.ORCID 0000-0003-4650-7520
Michel MoutschenDepartment of Infectious Diseases and General Internal Medicine, University Hospital of Liège, 4000 Liege, Belgium.
Simon DellicourDepartment of Microbiology, Immunology and Transplantation, Rega Institute, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-9558-1052
Gilles DarcisDepartment of Infectious Diseases and General Internal Medicine, University Hospital of Liège, 4000 Liege, Belgium.ORCID 0000-0001-8192-1351
University of Liège · BEKU Leuven · BECentre Hospitalier Universitaire de Liège · BERega Institute for Medical Research · BEUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Healthcare workers (HCWs) are known to be at higher risk of developing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections although whether these risks are equal across all occupational roles is uncertain. Identifying these risk factors and understand SARS-CoV-2 transmission pathways in healthcare settings are of high importance to achieve optimal protection measures. We aimed to investigate the implementation of a voluntary screening program for SARS-CoV-2 infections among hospital HCWs and to elucidate potential transmission pathways though phylogenetic analysis before the vaccination era. HCWs of the University Hospital of Liège, Belgium, were invited to participate in voluntary reverse transcriptase-polymerase chain reaction (RT-PCR) assays performed every week from April to December 2020. Phylogenetic analysis of SARS-CoV-2 genomes were performed for a subgroup of 45 HCWs. 5095 samples were collected from 703 HCWs. 212 test results were positive, 15 were indeterminate, and 4868 returned negative. 156 HCWs (22.2%) tested positive at least once during the study period. All SARS-CoV-2 test results returned negative for 547 HCWs (77.8%). Nurses (p < 0.05), paramedics (p < 0.05), and laboratory staff handling respiratory samples (p < 0.01) were at higher risk for being infected compared to the control non-patient facing group. Our phylogenetic analysis revealed that most positive samples corresponded to independent introduction events into the hospital. Our findings add to the growing evidence of differential risks of being infected among HCWs and support the need to implement appropriate protection measures based on each individual’s risk profile to guarantee the protection of both HCWs and patients. Furthermore, our phylogenetic investigations highlight that most positive samples correspond to distinct introduction events into the hospital.

Indexed as

COVID-19BelgiumDelivery of Health CareHealth PersonnelHospitals, UniversityHumansPersonnel, HospitalPhylogenySARS-CoV-2COVID-19healthcare-associated transmissionhealthcare workersinfection prevention and controloccupational exposurephylogenetic analysisSARS-CoV-2

Identifiers

PMID35746774
PMCPMC9227503
OpenAlexW4282938082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.