Evidence map›Paper›PMID 35746736›Full record

ArticleViruses2022

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4

Leon Cords, Maximilian Knapp, Robin Woost, Sophia Schulte, Silke Kummer, Christin Ackermann, Claudia Beisel, Sven Peine, Alexandra Märta Johansson, William Wai-Hung Kwok and 6 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Leon CordsInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-1340-8817
Maximilian KnappInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-9554-5067
Robin WoostInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Sophia SchulteInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Silke KummerInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Christin AckermannInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Claudia BeiselInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-4905-4646
Sven PeineInstitute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Alexandra Märta JohanssonBenaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.ORCID 0000-0003-4779-4648
William Wai-Hung KwokBenaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.ORCID 0000-0003-4843-4599
Thomas GüntherLeibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany.ORCID 0000-0001-9650-0218
Nicole FischerGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, 20246 Hamburg, Germany.ORCID 0000-0002-5092-8179
Melanie WittnerInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Marylyn Martina AddoInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0003-2836-9224
Samuel HuberInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-9325-8227
Julian Schulze Zur WieschInfectious Diseases Unit I, Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-5033-1938
Universität Hamburg · DELeibniz Institute of Virology (LIV) · DEVirginia Mason Medical Center · US

Funding

Project-002U19AI135817 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI KWOK, WILLIAM W. · 2018 to 2022
$6.8M
NIAID NIH HHS U19 AI135817NIH HHS NIDDK 3U19AI135817-04S1
6 · The paper itself

Abstract

Here, we longitudinally assessed the ex vivo frequency and phenotype of SARS-CoV-2 membrane protein (aa145-164) epitope-specific CD4

Indexed as

COVID-19SARS-CoV-2CD4-Positive T-LymphocytesHumansPhenotypeT-Lymphocytes, Helper-Induceranti-CD20 therapyCD39CD4+ T-cellsCD73COVID-19MHC class II TetramerPD-1SARS-CoV-2T-cell memoryTIGIT

Identifiers

PMID35746736
PMCPMC9228841
OpenAlexW4282837288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.