Evidence map›Paper›PMID 35746728›Full record

Observational studyViruses2022

High Incidence of SARS-CoV-2 Variant of Concern Breakthrough Infections Despite Residual Humoral and Cellular Immunity Induced by BNT162b2 Vaccination in Healthcare Workers: A Long-Term Follow-Up Study in Belgium.

Bas Calcoen, Nico Callewaert, Aline Vandenbulcke, Winnie Kerstens, Maya Imbrechts, Thomas Vercruysse, Kai Dallmeier, Johan Van Weyenbergh, Piet Maes, Xavier Bossuyt and 8 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. The characterization of CD8Emerging microbes & infections · 2024
    Review
  2. Article
  3. The role of immune activation and antigen persistence in acute and long COVID.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Bas CalcoenLaboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, 8500 Kortrijk, Belgium.
Nico CallewaertAZ Groeninge Hospital, Department of Laboratory Medicine, 8500 Kortrijk, Belgium.
Aline VandenbulckeLaboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, 8500 Kortrijk, Belgium.
Winnie KerstensLaboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, KU Leuven Rega Institute, 3000 Leuven, Belgium.
Maya ImbrechtsPharmAbs, the KU Leuven Antibody Center, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-4467-9831
Thomas VercruysseLaboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, KU Leuven Rega Institute, 3000 Leuven, Belgium.ORCID 0000-0002-8649-777X
Kai DallmeierLaboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Department of Microbiology, Immunology and Transplantation, KU Leuven Rega Institute, 3000 Leuven, Belgium.ORCID 0000-0002-8117-9166
Johan Van WeyenberghLaboratory for Clinical and Epidemiological Virology, KU Leuven Rega Institute, 3000 Leuven, Belgium.ORCID 0000-0003-3234-8426
Piet MaesLaboratory for Clinical and Epidemiological Virology, KU Leuven Rega Institute, 3000 Leuven, Belgium.
Xavier BossuytDepartment of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.
Dorinja ZapfInstitut für Experimentelle Immunologie, EUROIMMUN Medizinische Labordiagnostika AG, 23552 Lübeck, Germany.
Kersten DieckmannInstitut für Experimentelle Immunologie, EUROIMMUN Medizinische Labordiagnostika AG, 23552 Lübeck, Germany.
Kim CallebautAZ Groeninge Hospital, Department of Laboratory Medicine, 8500 Kortrijk, Belgium.
Hendrik Jan ThibautLaboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, KU Leuven Rega Institute, 3000 Leuven, Belgium.ORCID 0000-0001-5785-8276
Karen VanhoorelbekeLaboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, 8500 Kortrijk, Belgium.
Simon F De MeyerLaboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, 8500 Kortrijk, Belgium.
Wim MaesPharmAbs, the KU Leuven Antibody Center, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-4629-6674
Nick GeukensPharmAbs, the KU Leuven Antibody Center, KU Leuven, 3000 Leuven, Belgium.
Rega Institute for Medical Research · BEKU Leuven · BEResearch Institute for Chromatography · BEAZ Groeninge · BEEuroimmun Medizinische Labordiagnostika (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To mitigate the massive COVID-19 burden caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccination campaigns were initiated. We performed a single-center observational trial to monitor the mid- (3 months) and long-term (10 months) adaptive immune response and to document breakthrough infections (BTI) in healthcare workers (

Indexed as

COVID-19SARS-CoV-2Antibodies, NeutralizingAntibodies, ViralBelgiumBNT162 VaccineCD8-Positive T-LymphocytesDisease ProgressionFollow-Up StudiesHealth PersonnelHumansImmunity, CellularImmunity, HumoralIncidenceVaccinationAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineBNT162b2 vaccinebreakthrough infectionhealthcare workerslong-term monitoringSARS-CoV-2variants of concern

Identifiers

PMID35746728
PMCPMC9228150
OpenAlexW4282574856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.