Evidence map›Paper›PMID 35746657›Full record

ArticleViruses2022

Carriers of

Kristina Zguro, Margherita Baldassarri, Francesca Fava, Giada Beligni, Sergio Daga, Roberto Leoncini, Lucrezia Galasso, Michele Cirianni, Stefano Rusconi, Matteo Siano and 27 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 14 institutions in 2 countries.

Kristina ZguroMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Margherita BaldassarriMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-0391-1980
Francesca FavaMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-4363-2353
Giada BeligniMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Sergio DagaMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-6419-9456
Roberto LeonciniLaboratorio Patologia Clinica, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.
Lucrezia GalassoLaboratorio Patologia Clinica, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.
Michele CirianniLaboratorio Patologia Clinica, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.
Stefano RusconiInfectious Diseases Unit, ASST Ovest Milanese, 20025 Legnano, Italy.ORCID 0000-0002-0375-9990
Matteo SianoDepartment of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, 20157 Milan, Italy.
Daniela FrancisciInfectious Diseases Clinic, "Santa Maria della Misericordia" Hospital, University of Perugia, 06124 Perugia, Italy.
Elisabetta SchiaroliInfectious Diseases Clinic, "Santa Maria della Misericordia" Hospital, University of Perugia, 06124 Perugia, Italy.ORCID 0000-0002-3216-4144
Sauro LuchiInfectious Disease Unit, Hospital of Lucca, 55100 Lucca, Italy.
Giovanna MorelliInfectious Disease Unit, Hospital of Lucca, 55100 Lucca, Italy.
Enrico MartinelliDepartment of Respiratory Diseases, Azienda Ospedaliera di Cremona, 26100 Cremona, Italy.
Massimo GirardisDepartment of Anesthesia and Intensive Care, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0002-2453-0829
Stefano BusaniDepartment of Anesthesia and Intensive Care, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0003-0150-4967
Saverio Giuseppe ParisiDepartment of Molecular Medicine, University of Padova, 35121 Padova, Italy.
Sandro PaneseClinical Infectious Diseases, Mestre Hospital, 30171 Venezia, Italy.
Carmelo PiscopoMedical Genetics and Laboratory Genetics Unit, "Antonio Cardarelli" hospital, 80131 Naples, Italy.
Mario CapassoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80138 Naples, Italy.ORCID 0000-0003-3306-1259
Danilo TacconiDepartment of Specialized and Internal Medicine, Infectious Diseases Unit, San Donato Hospital Arezzo, 52100 Arezzo, Italy.
Chiara Spertilli RaffaelliDepartment of Specialized and Internal Medicine, Infectious Diseases Unit, San Donato Hospital Arezzo, 52100 Arezzo, Italy.
Annarita GilibertiMedical Genetics Unit, Meyer Children's University Hospital, 50134 Florence, Italy.
Giulia GoriMedical Genetics Unit, Meyer Children's University Hospital, 50134 Florence, Italy.ORCID 0000-0002-6026-4126
Peter D KatsikisDepartment of Immunology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-7690-5218
Maria LorubbioUOC Laboratorio Analisi Chimico Cliniche, 52100 Arezzo, Italy.
Paola CalzoniLaboratorio Patologia Clinica, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy.
Agostino OgnibeneUOC Laboratorio Analisi Chimico Cliniche, 52100 Arezzo, Italy.
Monica BocchiaHematology Unit, Department of Medical Science, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy.
Monica TozziStem Cell Transplant and Cellular Therapy Unit, University Hospital of Siena, 53100 Siena, Italy.
Alessandro BucalossiStem Cell Transplant and Cellular Therapy Unit, University Hospital of Siena, 53100 Siena, Italy.
Giuseppe MarottaStem Cell Transplant and Cellular Therapy Unit, University Hospital of Siena, 53100 Siena, Italy.
Simone FuriniMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Gen-Covid Multicenter Study
Alessandra RenieriMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-0846-9220
Chiara FalleriniMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-7386-3224
University of Siena · ITAzienda Ospedaliera Universitaria Senese · ITAzienda Usl 8 Arezzo · ITIMT School for Advanced Studies Lucca · ITMeyer Children's Hospital · ITOspedale San Donato · ITUniversity of Milan · ITUniversity of Modena and Reggio Emilia · ITUniversity of Perugia · ITAziende Socio Sanitarie Territoriale di CremaCeinge Biotecnologie Avanzate (Italy) · ITErasmus MC · NLOspedale Antonio Cardarelli · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombosis of small and large vessels is reported as a key player in COVID-19 severity. However, host genetic determinants of this susceptibility are still unclear. Congenital Thrombotic Thrombocytopenic Purpura is a severe autosomal recessive disorder characterized by uncleaved ultra-large vWF and thrombotic microangiopathy, frequently triggered by infections. Carriers are reported to be asymptomatic. Exome analysis of about 3000 SARS-CoV-2 infected subjects of different severities, belonging to the GEN-COVID cohort, revealed the specific role of vWF cleaving enzyme

Indexed as

COVID-19Purpura, Thrombotic ThrombocytopenicADAM ProteinsADAMTS13 ProteinHumansSARS-CoV-2von Willebrand FactorADAM ProteinsADAMTS13 ProteinADAMTS13 protein, humanvon Willebrand FactorADAMTS13add-on therapyCOVID-19thromboembolism

Identifiers

PMID35746657
PMCPMC9227269
OpenAlexW4283452310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.