Evidence map›Paper›PMID 35746639›Full record

ArticleViruses2022

Simian Varicella Virus Pathogenesis in Skin during Varicella and Zoster.

Ravi Mahalingam, Brittany Feia, Colin Coleman, Kusala Anupindi, Pratush Saravanan, Amalia Luthens, Amalia Bustillos, Arpita Das, Eileen de Haro, Lara Doyle-Meyers and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Ravi MahalingamDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Brittany FeiaDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Colin ColemanCell and Developmental Biology Program, School of Medicine, Oregon Health Sciences University, Portland, OR 97201, USA.
Kusala AnupindiDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Pratush SaravananDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-2349-8679
Amalia LuthensDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Amalia BustillosDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Arpita DasDivision of Microbiology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.
Eileen de HaroDivision of Microbiology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.
Lara Doyle-MeyersDivision of Microbiology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.
Jayme LooperDepartment of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.ORCID 0000-0001-7296-4413
Andrew N BubakDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Christy S NiemeyerDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Brent PalmerDivision of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Maria A NagelDepartment of Neurology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.
Vicki Traina-DorgeDivision of Microbiology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.
University of Colorado Anschutz Medical Campus · USTulane University · USLouisiana State University · USOregon Health & Science University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
VARICELLA ZOSTER VIRUS VASCULOPATHY: CHANGING CLINICAL PRACTICEP01AG032958 · NIA · UNIVERSITY OF COLORADO DENVER · PI NAGEL, MARIA ACENA · 2009 to 2023
$30.3M
NIA NIH HHS P01 AG032958NIH HHS P01 AG032958NIH HHS P51 OD011104
6 · The paper itself

Abstract

Primary simian varicella virus (SVV) infection and reactivation in nonhuman primates is a valuable animal model in the study of varicella zoster virus disease [varicella (chickenpox) and herpes zoster (shingles)]. To understand SVV pathogenesis in skin, we inoculated 10 rhesus macaques with SVV, resulting in varicella rash. After the establishment of latency, eight of the monkeys were immunosuppressed using tacrolimus with or without irradiation and prednisone and two monkeys were not immunosuppressed. Zoster rash developed in all immunosuppressed monkeys and in one non-immunosuppressed monkey. Five monkeys had recurrent zoster. During varicella and zoster, SVV DNA in skin scrapings ranged from 50 to 10

Indexed as

ChickenpoxExanthemaHerpes ZosterVaricellovirusAnimalsHerpesvirus 3, HumanMacaca mulattasimian varicella virusskin pathogenesisvaricellazoster

Identifiers

PMID35746639
PMCPMC9227806
OpenAlexW4281738522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.