Evidence map›Paper›PMID 35746561›Full record

ArticleVaccines2022

A New Live Auxotrophic Vaccine Induces Cross-Protection against

Miriam Moscoso, Juan A Vallejo, Maria P Cabral, Patricia García, Víctor Fuentes-Valverde, Eva Gato, Jorge Arca-Suárez, Pablo Aja-Macaya, Germán Bou

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Materials today. Bio · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Vaccines · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Miriam MoscosoDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.ORCID 0000-0001-8977-3269
Juan A VallejoDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.ORCID 0000-0002-7581-8654
Maria P CabralDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.
Patricia GarcíaDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.ORCID 0000-0002-0418-296X
Víctor Fuentes-ValverdeDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.ORCID 0000-0002-1827-7003
Eva GatoDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.
Jorge Arca-SuárezDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.
Pablo Aja-MacayaDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.
Germán BouDepartment of Microbiology, University Hospital A Coruña (CHUAC)-Biomedical Research Institute A Coruña (INIBIC), 15006 A Coruña, Spain.ORCID 0000-0001-8837-0062
Complexo Hospitalario Universitario A Coruña · ESInstituto de Salud Carlos III · ES

Funding

Centro de Investigación Biomédica en Red de Enfermedades Infecciosas CIBERINFECConsellería de Cultura, Educación e Ordenación Universitaria IN606A-2019/012Instituto de Salud Carlos III PI18/00501Instituto de Salud Carlos III PI21/00704Red Espanola de Investigacion en Patologia Infecciosa RD16/0016/0006Servicio Gallego de Salud Innova Saúde
6 · The paper itself

Abstract

The development of a whole-cell vaccine from bacteria auxotrophic for D-amino acids present in the bacterial cell wall is considered a promising strategy for providing protection against bacterial infections. Here, we constructed a prototype vaccine, consisting of a glutamate racemase-deficient mutant, for preventing

Indexed as

cross-protectionD-glutamate auxotrophyglutamate racemaseKlebsiella pneumoniaelive vaccines

Identifiers

PMID35746561
PMCPMC9227041
OpenAlexW4283164896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.