Evidence map›Paper›PMID 35746506›Full record

ArticleVaccines2022

Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study.

Nicola Veronese, Lee Smith, Francesco Di Gennaro, Olivier Bruyère, Lin Yang, Jacopo Demurtas, Stefania Maggi, Shaun Sabico, Nasser M Al-Daghri, Mario Barbagallo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 6 countries.

Nicola VeroneseGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-9328-289X
Lee SmithCenter for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PTT, UK.ORCID 0000-0002-5340-9833
Francesco Di GennaroClinic of Infectious Diseases, University of Bari, 70121 Bari, Italy.ORCID 0000-0003-3453-5647
Olivier BruyèreDepartment of Public Health, Epidemiology and Health Economics, University of Liège, 4000 Liège, Belgium.ORCID 0000-0003-4269-9393
Lin YangDepartment of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Edmonton, AB T5J 3E4, Canada.ORCID 0000-0002-1698-6666
Jacopo DemurtasPrimary Care Department, Azienda USL Toscana Sud Est, 52100 Grosseto, Italy.
Stefania MaggiInstitute of Neuroscience, National Research Council, 00185 Padova, Italy.ORCID 0000-0002-0453-8663
Shaun SabicoChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-5248-2350
Nasser M Al-DaghriChair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-5472-1725
Mario BarbagalloGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-1349-6530
Ligia J DominguezGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, Italy.
Ai KoyanagiParc Sanitari Sant Joan de Déu/CIBERSAM, ISCIII, Universitat de Barcelona, Fundació Sant Joan de Déu, Sant Boi de Llobregat, 08014 Barcelona, Spain.
King Saud University · SAUniversity of Palermo · ITAlberta Health Services · CAAnglia Ruskin University · GBInstitució Catalana de Recerca i Estudis Avançats · ESNational Research Council · ITUniversità degli Studi di Enna Kore · ITUniversity of Bari Aldo Moro · ITUniversity of Liège · BEUniversity of Modena and Reggio Emilia · IT

Funding

NIA NIH HHS HHSN271201300071C
6 · The paper itself

Abstract

Existing literature on the association between influenza vaccination and COVID-19 infection/outcomes is conflicting. Therefore, we aimed to investigate the association between influenza vaccination and COVID-19 outcomes in a large cohort of adults who participated in the SHARE (Survey of Health, Ageing, and Retirement in Europe). Information regarding influenza vaccination in the previous year, and medical and demographic characteristics, were self-reported. Positivity for COVID-19, symptomatology, and hospitalization were also ascertained using self-reported information. An adjusted logistic regression analysis (including 15 baseline factors or propensity score) was used to assess the association between influenza vaccination and COVID-19 outcomes. A total of 48,408 participants (mean age 67 years; 54.1% females) were included. The prevalence of influenza vaccination was 38.3%. After adjusting for 15 potential confounders, influenza vaccination was significantly associated with a lower risk of positivity for COVID-19 (OR = 0.95; p < 0.0001), symptomatic forms (OR = 0.87; p < 0.0001), and hospitalization for COVID-19 (OR = 0.95; p < 0.0001). The results were similar when using a propensity score approach. In conclusion, influenza vaccination may be beneficial for the prevention of COVID-19, as the present study found that influenza vaccination was associated with a small/moderate lower risk of COVID-19 infection and adverse outcomes.

Indexed as

COVID-19influenzaSHARE studyvaccination

Identifiers

PMID35746506
PMCPMC9229857
OpenAlexW4281853699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.