ArticleVaccines2022
The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad.
Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Vaccination Status in Pregnancy: A Cross-Sectional Study of Two Greek Maternity Hospitals.Journal of pregnancy · 2026Article
- Predicting Risk for Patent Ductus Arteriosus in the Neonate: A Machine Learning Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Influence of Maternal and Neonatal Factors on Transplacental Passive Immunity after Vaccination against COVID-19.Vaccines · 2024Article
- IgG antibody levels against the SARS-CoV-2 spike protein in mother-child dyads after COVID-19 vaccination.Infection · 2024Article
- COVID-Vaccines in Pregnancy: Maternal and Neonatal Response over the First 9 Months after Delivery.Biomolecules · 2024Article
- SARS-CoV-2 Seroprevalence in Children under 5 Years Old-A Regional Seroepidemiological Study.Medicina (Kaunas, Lithuania) · 2024Article
- SARS-CoV-2 anti-RBD and anti-N protein responses are differentially regulated between mother-child pairs: insight from a national study cohort at the Faroe Islands.Frontiers in immunology · 2024Article
- A preliminary study on the effectiveness of maternal to neonatal transfer of antibodies against SARS-CoV-2 in the women vaccinated with heterologous CoronaVac-ChAdOx1.Human vaccines & immunotherapeutics · 2023Article
- Vertical transmission and maternal passive immunity post-SARS-CoV-2.Future virology · 2023Review
- Review
- An Update on COVID-19 Vaccination and Pregnancy.Journal of personalized medicine · 2023Review
- Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy.Vaccines · 2023Article
- Review
- Placental Transfer Immunity to the Newborns in a Twin Pregnant Women Vaccinated with Heterologous CoronaVac-ChAdOx1.Vaccines · 2023Article
- Cytokines and Chemokines in Breastmilk of SARS-CoV-2 Infected or COVID-19 Vaccinated Mothers.Vaccines · 2022Article
- Durable antibody and effector memory T cell responses in breastmilk from women with SARS-CoV-2.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, t(90) = 8.91, p < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.