Evidence map›Paper›PMID 35746058›Full record

ArticlePolymers2022

Preparation and Release of pH-Sensitive β-Cyclodextrin Derivative Micelles Loaded with Paclitaxel.

Meirong Zhao, Weiwei Jiang, Xinrong Xie, Yogini Jaiswal, Leonard Williams, Mei Wei, Ying Mo, Yifu Guan, Hua Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Meirong ZhaoSchool of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Weiwei JiangCollege of Medicine, Guangxi University, Nanning 530004, China.
Xinrong XieSchool of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Yogini JaiswalCenter for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 2802, USA.
Leonard WilliamsCenter for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 2802, USA.ORCID 0000-0003-0886-5204
Mei WeiDepartment of Pharmacy, Guangxi Agricultural Vocational University, Nanning 530021, China.
Ying MoDepartment of Pharmacy, Guangxi Agricultural Vocational University, Nanning 530021, China.
Yifu GuanSchool of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China.
Hua YangCollege of Medicine, Guangxi University, Nanning 530004, China.
Minzu University of China · CNGuangxi University · CNNanning Normal University · CNNorth Carolina Agricultural and Technical State University · US

Funding

the Foundation of key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) CHEMR2019-B09the Natural Science Foundation of Guangxi AD20238016the Research Start-up Foundation of Guangxi University for Nationalities 2019KJQD07
6 · The paper itself

Abstract

In this paper, a new amphiphilic mono-6-β-cyclodextrin octadecylimine (6-β-CD-N-ODMA) copolymer was synthesized based on β-cyclodextrin and octadecylamine, which can self-assemble to form polymeric micelles. Drug-loaded micelles (a new drug carrier) were obtained using 6-β-CD-N-ODMA and paclitaxel (PTX) by the dialysis method. Orthogonal experiments were used to optimize the preparation method of the drug-loaded micelles. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The physicochemical properties of blank micelles and drug-loaded micelles were evaluated by the fluorescence probe method, infrared spectra, dynamic light scattering, and scanning electron microscopy. The release properties of the carrier were investigated. The carrier has good pH sensitivity and the cumulative release rate after 96 h was 88% in PBS (pH = 5.0). The Ritger-Peppas equation is the optimal model for PTX released at pH 5.0, implying that the hydrolysis effect of 6-β-CD-N-ODMA is the main reason for PTX release. The results indicate that the developed carrier can increase the solubility of PTX and possess potential for increased clinical efficacy of PTX.

Indexed as

paclitaxelpH-sensitivepolymer micellesreleaseβ-cyclodextrin

Identifiers

PMID35746058
PMCPMC9227914
OpenAlexW4283157313

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.