Evidence map›Paper›PMID 35746017›Full record

ArticlePolymers2022

Antiseptic Polymer-Surfactant Complexes with Long-Lasting Activity against SARS-CoV-2.

Vyacheslav S Molchanov, Andrey V Shibaev, Eduard V Karamov, Viktor F Larichev, Galina V Kornilaeva, Irina T Fedyakina, Ali S Turgiev, Olga E Philippova, Alexei R Khokhlov

Abstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Virucidal Coatings Active Against SARS-CoV-2.Molecules (Basel, Switzerland) · 2024
    Article
  3. Double Photocrosslinked Responsive Hydrogels Based on Hydroxypropyl Guar.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vyacheslav S MolchanovPhysics Department, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-2846-0784
Andrey V ShibaevPhysics Department, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-3019-5764
Eduard V KaramovGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.ORCID 0000-0003-1162-118X
Viktor F LarichevGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Galina V KornilaevaGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Irina T FedyakinaGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Ali S TurgievGamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Olga E PhilippovaPhysics Department, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-1098-0255
Alexei R KhokhlovPhysics Department, Lomonosov Moscow State University, 119991 Moscow, Russia.

Funding

Russian Foundation for Basic Research 20-04-60302
6 · The paper itself

Abstract

Antiseptic polymer gel-surfactant complexes were prepared by incorporating the low-molecular-weight cationic disinfectant cetylpyridinium chloride into the oppositely charged, slightly cross-linked polymer matrices. Three types of polymers were used: copolymers of acrylamide and sodium 2-acrylamido-2-methylpropane sulfonate; copolymers of acrylamide and sodium methacrylate; copolymers of vinylpyrrolidone and sodium methacrylate. It was shown that the rate of the release of the cationic disinfectant from the oppositely charged polymer gels could be tuned in a fairly broad range by varying the concentration of the disinfectant, the degree of swelling, and degree of cross-linking of the gel and the content/type of anionic repeat units in the polymer matrix. Polymer-surfactant complexes were demonstrated to reduce SARS-CoV-2 titer by seven orders of magnitude in as little as 5 s. The complexes retained strong virucidal activity against SARS-CoV-2 for at least one week.

Indexed as

COVID-19disinfectanthydrogelpolyacrylamidepolyelectrolyteSARS-CoV-2surfactant

Identifiers

PMID35746017
PMCPMC9228194

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.