Evidence map›Paper›PMID 35745954›Full record

ReviewPolymers2022

Thermosensitive Hydrogels and Advances in Their Application in Disease Therapy.

Ranran Fan, Yi Cheng, Rongrong Wang, Ting Zhang, Hui Zhang, Jianchun Li, Shenghan Song, Aiping Zheng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.

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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Ranran FanSchool of Pharmacy, Bengbu Medical College, Anhui 233030, China.
Yi ChengCollege of Pharmacy, Yanbian University, Jilin 133002, China.
Rongrong WangSchool of Pharmacy, North China University of Science and Technology, Hebei 063210, China.
Ting ZhangSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Hui ZhangInstitute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China.
Jianchun LiSchool of Pharmacy, Bengbu Medical College, Anhui 233030, China.
Shenghan SongDepartment of Vascular Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Aiping ZhengInstitute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China.
Academy of Military Medical Sciences · CNBengbu Medical College · CNCapital Medical University · CNNorth China University of Science and Technology · CNYanbian University · CNZhengzhou University · CN

Funding

National Natural Science Foundation of China 81573357
6 · The paper itself

Abstract

Thermosensitive hydrogels, having unique sol-gel transition properties, have recently received special research attention. These hydrogels exhibit a phase transition near body temperature. This feature is the key to their applications in human medicine. In addition, hydrogels can quickly gel at the application site with simple temperature stimulation and without additional organic solvents, cross-linking agents, or external equipment, and the loaded drugs can be retained locally to improve the local drug concentration and avoid unexpected toxicity or side effects caused by systemic administration. All of these features have led to thermosensitive hydrogels being some of the most promising and practical drug delivery systems. In this paper, we review thermosensitive hydrogel materials with biomedical application potential, including natural and synthetic materials. We describe their structural characteristics and gelation mechanism and briefly summarize the mechanism of drug release from thermosensitive hydrogels. Our focus in this review was to summarize the application of thermosensitive hydrogels in disease treatment, including the postoperative recurrence of tumors, the delivery of vaccines, the prevention of postoperative adhesions, the treatment of nervous system diseases via nasal brain targeting, wound healing, and osteoarthritis treatment.

Indexed as

disease treatmentdrug deliverydrug release mechanismlocal administrationthermosensitive hydrogel

Identifiers

PMID35745954
PMCPMC9227257
OpenAlexW4282601026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.