Evidence map›Paper›PMID 35745823›Full record

ArticlePharmaceutics2022

A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis.

Caroline De Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D'Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M Moreira and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Caroline De Souza PereiraLaboratório de Química Bioinorgânica e Catálise, Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora 36036-900, Brazil.
Helenita Costa QuadrosInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil.ORCID 0000-0002-7191-4809
Samuel Yaw AboagyeDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0000-0001-7702-982X
Diana FontinhaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.ORCID 0000-0002-0046-648X
Sarah D'AlessandroDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-9241-9762
Margaret Elizabeth ByrneDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612, USA.
Mathieu GendrotUnité Parasitologie et Entomologie, Institut de Recherche Biomédicale des Armées, 13005 Marseille, France.ORCID 0000-0002-2322-5427
Isabelle FontaUnité Parasitologie et Entomologie, Institut de Recherche Biomédicale des Armées, 13005 Marseille, France.
Joel MosnierUnité Parasitologie et Entomologie, Institut de Recherche Biomédicale des Armées, 13005 Marseille, France.
Diogo Rodrigo M MoreiraInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil.ORCID 0000-0003-3323-4404
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universitá Degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-9030-1066
David L WilliamsDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL 60612, USA.ORCID 0000-0002-6815-4909
Miguel PrudêncioInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.ORCID 0000-0003-1746-6029
Bruno PradinesUnité Parasitologie et Entomologie, Institut de Recherche Biomédicale des Armées, 13005 Marseille, France.ORCID 0000-0002-2360-3803
Maribel NavarroLaboratório de Química Bioinorgânica e Catálise, Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora 36036-900, Brazil.ORCID 0000-0002-8772-0312

Funding

Identification of preclinical drug candidates for the treatment of schistosomiasisR33AI127635 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI PETUKHOV, PAVEL A, THATCHER, GREGORY R. J · 2019 to 2021
$1.3M
Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Délégation Générale pour l'Armement PDH-2-NRBC-4-B-4104Fondazione Cariplo 2017-0846Fundação de Amparo à Pesquisa do Estado da Bahia APP0088/2016Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-01543-18Fundação para a Ciência e Tecnologia INF- 29550-2017Ministero dell'Istruzione, dell'Università e della Ricerca PRIN 2015.4JRJPP_004National Council for Scientific and Technological Development 306009/2020-0; 305732/2019-6NIAID NIH HHS R33 AI127635Oswaldo Cruz Foundation IGM-002-FIO-20-2-25Santé Publique France CNR du Paludisme
6 · The paper itself

Abstract

Hybrid-based drugs linked through a transition metal constitute an emerging concept for

Indexed as

antimalarial drugsflavoenzymesgoldheme detoxificationhemozoinmalariaPlasmodiumquinolinesredox homeostasis

Identifiers

PMID35745823
PMCPMC9229949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.