Evidence map›Paper›PMID 35745764›Full record

ArticlePharmaceutics2022

Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents.

Paola Oliva, Romeo Romagnoli, Barbara Cacciari, Stefano Manfredini, Chiara Padroni, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic and 4 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Paola OlivaDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
Romeo RomagnoliDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-6374-773X
Barbara CacciariDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
Stefano ManfrediniDepartment of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-1348-4422
Chiara PadroniMedicinal Chemistry Department, Integrated Drug Discovery, Aptuit-An Evotec Company, Via A. Fleming, 37135 Verona, Italy.
Andrea BrancaleSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.ORCID 0000-0002-9728-3419
Salvatore FerlaSwansea University Medical School, Institute of Life Sciences 2, Swansea University, Swansea SA2 8PP, UK.ORCID 0000-0002-5918-9237
Ernest HamelMolecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Diana CoralloLaboratory of Target Discovery and Biology of Neuroblastoma, Istituto di Ricerca Pediatrica (IRP), Fondazione Città della Speranza, Padova, Corso Stati Uniti 4, 35128 Padova, Italy.
Sanja AveicLaboratory of Target Discovery and Biology of Neuroblastoma, Istituto di Ricerca Pediatrica (IRP), Fondazione Città della Speranza, Padova, Corso Stati Uniti 4, 35128 Padova, Italy.ORCID 0000-0002-3886-4360
Noemi MilanHemato-Oncology Lab, Department of Woman's and Child's Health, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-1204-3142
Elena MariottoHemato-Oncology Lab, Department of Woman's and Child's Health, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-3960-8561
Giampietro ViolaHemato-Oncology Lab, Department of Woman's and Child's Health, University of Padova, 35131 Padova, Italy.ORCID 0000-0001-9329-165X
Roberta BortolozziHemato-Oncology Lab, Department of Woman's and Child's Health, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-3357-4815
University of Ferrara · ITUniversity of Padua · ITCittà della Speranza Foundation · ITAptuit (Italy) · ITCardiff University · GBNational Institutes of Health · USSwansea University · GB

Funding

CCR NIH HHS HHSN261200800001CMinistry of Education, Universities and Research 2017E84AA4_002NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Two different series of fifty-two compounds, based on 3',4',5'-trimethoxyaniline (

Indexed as

[1,2,4]triazolo [1,5-a]pyrimidineantimitotic agentsantiproliferative activitystructure–activity relationshiptubulin polymerization

Identifiers

PMID35745764
PMCPMC9230136
OpenAlexW4281723522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.