Evidence map›Paper›PMID 35745731›Full record

ArticlePharmaceutics2022

In Vitro Activity of Ebselen and Diphenyl Diselenide Alone and in Combination with Drugs against

Sebastian Gnat, Dominik Łagowski, Mariusz Dyląg, Grzegorz Jóźwiak, Aleksandra Trościańczyk, Aneta Nowakiewicz

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Efficacy of selenium- and tellurium-based organocompounds against ruminant gastrointestinal nematodes in vitro.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sebastian GnatDepartment of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland.ORCID 0000-0001-9872-0046
Dominik ŁagowskiDepartment of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland.ORCID 0000-0002-7846-5444
Mariusz DylągDepartment of Mycology and Genetics, Faculty of Biological Sciences, University of Wroclaw, S. Przybyszewskiego 63, 50-137 Wroclaw, Poland.ORCID 0000-0003-2062-6169
Grzegorz JóźwiakDepartment of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.ORCID 0000-0001-5071-3154
Aleksandra TrościańczykDepartment of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland.
Aneta NowakiewiczDepartment of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland.ORCID 0000-0003-3961-5291

Funding

University of Life Sciences in Lublin WKD/MN-2/WET/21
6 · The paper itself

Abstract

backgroundDermatophytoses are one of the most prevalent infectious diseases in the world for which the pace of developing new drugs has not kept pace with the observed therapeutic problems. Thus, searching for new antifungals with an alternative and novel mechanism of action is necessary.

objectiveThis study aimed to evaluate the antifungal activity of ebselen and diphenyl diselenide against

methodsIn vitro antifungal susceptibility was assessed for organoselenium compounds used alone or in combination with allylamines and azoles according to the 3rd edition of the CLSI M38 protocol.

resultsEbselen demonstrated high antifungal activity with MIC

conclusionsThe results highlight the promising activity of organoselenium compounds against

Indexed as

antifungal therapydermatophytesdiphenyl diselenideebselenTrichophyton mentagrophytes

Identifiers

PMID35745731
PMCPMC9229022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.