Evidence map›Paper›PMID 35745710›Full record

ArticlePharmaceutics2022

Characterization of Physical and Biological Properties of a Caries-Arresting Liquid Containing Copper Doped Bioglass Nanoparticles.

Se-Jung Bang, Soo-Kyung Jun, Yu-Jin Kim, Jun-Yong Ahn, Huong Thu Vu, Nandin Mandakhbayar, Mi-Ran Han, Jun-Haeng Lee, Jong-Bin Kim, Jong-Soo Kim and 5 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities.Dental materials : official publication of the Academy of Dental Materials · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Copper Materials for Caries Management: A Scoping Review.Journal of functional biomaterials · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Se-Jung BangDepartment of Pediatric Dentistry, College of Dentistry, Dankook University, Cheonan 31116, Korea.ORCID 0000-0002-2218-6817
Soo-Kyung JunDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Korea.
Yu-Jin KimDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Korea.
Jun-Yong AhnDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Korea.
Huong Thu VuInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea.ORCID 0000-0001-5222-6042
Nandin MandakhbayarInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea.
Mi-Ran HanDepartment of Pediatric Dentistry, College of Dentistry, Dankook University, Cheonan 31116, Korea.ORCID 0000-0003-0312-6023
Jun-Haeng LeeDepartment of Pediatric Dentistry, College of Dentistry, Dankook University, Cheonan 31116, Korea.
Jong-Bin KimDepartment of Pediatric Dentistry, College of Dentistry, Dankook University, Cheonan 31116, Korea.ORCID 0000-0001-8744-9553
Jong-Soo KimDepartment of Pediatric Dentistry, College of Dentistry, Dankook University, Cheonan 31116, Korea.
Jonathan C KnowlesDepartment of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea.ORCID 0000-0003-3917-3446
Hye-Sung KimDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Korea.ORCID 0000-0002-2182-301X
Hae-Hyoung LeeDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Korea.ORCID 0000-0001-7224-5507
Ji-Sun ShinDepartment of Pediatric Dentistry, College of Dentistry, Dankook University, Cheonan 31116, Korea.ORCID 0000-0003-2147-5163
Jung-Hwan LeeDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Korea.ORCID 0000-0001-8678-5459
Dankook University · KRThe Royal Free Hospital · GBHanseo University · KR

Funding

National Research Foundation of Korea 2020R1G1A1009155, 2018K1A4A3A01064257, 2019R1A6A1A11034536, 2021R1A5A2022318, 2021R1C1C1010005
6 · The paper itself

Abstract

Silver diamine fluoride (SDF) is an outstanding dental material for arresting and preventing caries, but some drawbacks, such as high flowability due to low viscosity and cytotoxicity to the pulp, have been reported. To overcome these problems, copper-doped bioactive glass nanoparticles (CuBGns) were combined with SDF. After synthesis, CuBGns were examined by physical analysis and added in SDF at different weight/volume% (SDF@CuBGn). After assessing physical properties (viscosity and flowability) of SDF@CuBGn, physicochemical properties (morphology before and after simulated body fluid (SBF) immersion and ion release) of SDF@CuBGn-applied hydroxyapatite (HA) discs were evaluated. Biological properties were further evaluated by cytotoxicity test to pulp stem cells and antibacterial effect on cariogenic organisms (

Indexed as

biological propertiescopper-doped bioactive glass nanoparticlehydroxyapatite discphysicochemical propertiespulp stem cellssilver diamine fluorideStaphylococcus aureusStreptococcus mutansviscosity

Identifiers

PMID35745710
PMCPMC9227760
OpenAlexW4281755551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.