Evidence map›Paper›PMID 35745690›Full record

ArticlePharmaceutics2022

Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with

Hojun Choi, Myung-Yoon Kim, Dae-Hwan Kim, Hanoul Yun, Byung-Koo Oh, Su-Bin Kim, In-Ho Song, Hyun-Soo Park, Sang-Eun Kim, Cheolhyoung Park and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hojun ChoiILIAS Biologics Inc., Daejeon 34014, Korea.ORCID 0000-0002-8657-9548
Myung-Yoon KimILIAS Biologics Inc., Daejeon 34014, Korea.
Dae-Hwan KimILIAS Biologics Inc., Daejeon 34014, Korea.
Hanoul YunILIAS Biologics Inc., Daejeon 34014, Korea.
Byung-Koo OhILIAS Biologics Inc., Daejeon 34014, Korea.
Su-Bin KimDepartment of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.
In-Ho SongDepartment of Nuclear Medicine, Seoul National University Bundang Hospital 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam 13620, Korea.
Hyun-Soo ParkDepartment of Nuclear Medicine, Seoul National University Bundang Hospital 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam 13620, Korea.ORCID 0000-0001-7177-604X
Sang-Eun KimDepartment of Nuclear Medicine, Seoul National University Bundang Hospital 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam 13620, Korea.
Cheolhyoung ParkILIAS Biologics Inc., Daejeon 34014, Korea.
Chulhee ChoiILIAS Biologics Inc., Daejeon 34014, Korea.
Seoul National University · KRKorea Advanced Institute of Science and Technology · KRSeoul National University Bundang Hospital · KR

Funding

Ministry of Science ICT and Future Planning NRF-2016M3A9B6945831
6 · The paper itself

Abstract

For the successful clinical advancement of exosome therapeutics, the biodistribution and pharmacokinetic profile of exogenous exosomes in various animal models must be determined. Compared with fluorescence or bioluminescence imaging, radionuclide imaging confers multiple advantages for the in vivo tracking of biomolecular therapeutics because of its excellent sensitivity for deep tissue imaging and potential for quantitative measurement. Herein, we assessed the quantitative biodistribution and pharmacokinetics of good manufacturing practice-grade therapeutic exosomes labeled with zirconium-89 (

Indexed as

biodistributionexosomepharmacokineticspositron emission tomography/computed tomographyzirconium

Identifiers

PMID35745690
PMCPMC9229812
OpenAlexW4281481945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.