ArticlePharmaceuticals (Basel, Switzerland)2022
Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer's Disease.
Open access · goldAbstract read
In one paragraph
Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease.MedComm · 2026Review
- Evaluation of increased oxidative stress in the brain of patients with early Alzheimer's disease byJournal of neural transmission (Vienna, Austria : 1996) · 2026Article
- An integrated anti-aging framework targeting NADRedox biology · 2026Review
- Potential Protection Against Parkinson's Disease by Ergothioneine-Nature's Multifactorial Neuroprotectant.Antioxidants (Basel, Switzerland) · 2026Review
- Ergothioneine promotes osteogenesis and angiogenesis through PI3K/AKT pathway and prevents glucocorticoid-induced osteonecrosis of the femoral head.Scientific reports · 2026Article
- Ergothioneine-rich water extracts ofFrontiers in nutrition · 2026Article
- Serum ergothioneine and risk of dementia in a general older Japanese population: the Hisayama Study.Psychiatry and clinical neurosciences · 2025Article
- Advances and prospects of ergothioneine in the treatment of cognitive frailty.Annals of medicine · 2025Review
- N-Acetylcysteine Attenuates Aβ-Mediated Oxidative Stress, Blood-Brain Barrier Leakage, and Renal Dysfunction in 5xFAD Mice.International journal of molecular sciences · 2025Article
- Review
- Understanding mechanisms of antioxidant action in health and disease.Nature reviews. Molecular cell biology · 2024Review
- Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer's Disease.Foods (Basel, Switzerland) · 2023Review
- Relationship between the concentration of ergothioneine in plasma and the likelihood of developing pre-eclampsia.Bioscience reports · 2023Article
- Tracing the Path between Mushrooms and Alzheimer's Disease-A Literature Review.Molecules (Basel, Switzerland) · 2023Review
- Axonal energy metabolism, and the effects in aging and neurodegenerative diseases.Molecular neurodegeneration · 2023Review
- Multiple Metabolites Derived from Mushrooms and Their Beneficial Effect on Alzheimer's Diseases.Nutrients · 2023Review
- MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer's disease.Life science alliance · 2023Article
- Review
- Article
- Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer's disease.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Clayton A WhitmoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Justin R HaynesVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
William J BehofVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Adam J RosenbergVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-2459-7043
Mohammed N TantawyVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Brian C HacheyDepartment of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.
Brian E WadzinskiDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37233, USA.
Benjamin W SpillerDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37233, USA.
Todd E PetersonVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Krista C PaffenrothDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37233, USA.
Fiona E HarrisonVanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-1121-0647
Robert B BeelmanDepartment of Food Science, Center for Plant and Mushroom Foods for Health, Penn State University, University Park, PA 16802, USA.
Printha WijesingheDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z 3N9, Canada.
Joanne A MatsubaraDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z 3N9, Canada.
Wellington PhamVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Vanderbilt University · USVanderbilt University Medical Center · USUniversity of British Columbia · CAPennsylvania State University · US
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3MValidation of Retinal Abeta as a Potential Biomarker of Alzheimer's DiseaseR01AG061138 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHAM, WELLINGTON · 2019 to 2023
$3.6MPET System for Preclinical ResearchS10OD016245 · OD · VANDERBILT UNIVERSITY · PI PETERSON, TODD E · 2013 to 2013
$584kNCATS NIH HHS UL1 TR002243NIA NIH HHS AG061138NIA NIH HHS R01 AG061138NICHD NIH HHS P50 HD103537NIH HHS S10 OD016245
Abstract
PubMed holds no abstract for this paper.
Indexed as
5XFADAlzheimerergothioneineoxidative stressPETROS
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.