Evidence map›Paper›PMID 35745617›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Antiproliferative Activity of a New Quinazolin-4(3

Ji Yun Lee, Huarong Yang, Donghwa Kim, Kay Zin Kyaw, Ruoci Hu, Yanhua Fan, Sang Kook Lee

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ji Yun LeeNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.ORCID 0000-0002-5969-1315
Huarong YangThe Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550014, China.
Donghwa KimNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.ORCID 0000-0003-1425-213X
Kay Zin KyawNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Ruoci HuNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Yanhua FanThe Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550014, China.
Sang Kook LeeNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.ORCID 0000-0002-4306-7024
Seoul National University · KRGuiyang Medical University · CNKey Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences · CN

Funding

National Natural Science Foundation of China 21907020National Research Foundation of Korea 2019R1A2C2086476Natural Science Foundation of Guizhou Provincial Science and Technology Projects QKH-zk [2022]030
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is the most common lung cancer subtype. Although chemotherapy and targeted therapy are used for the treatment of patients with NSCLC, the survival rate remains very low. Recent findings suggested that aurora kinase A (AKA), a cell cycle regulator, is a potential target for NSCLC therapy. Previously, we reported that a chemical entity of quinazolin-4(3

Indexed as

aurora kinase Acombination therapyEGFR-TKIEGFR-TKI resistanceG2/M cell cycle arrestnon-small cell lung cancerquinazolin-4(3H)-one derivative

Identifiers

PMID35745617
PMCPMC9228987
OpenAlexW4281753199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.