Evidence map›Paper›PMID 35745589›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway.

Anthony Marchand, Joyce W M Van Bree, Aya C Taki, Mati Moyat, Gerardo Turcatti, Marc Chambon, Adam Alexander Thil Smith, Rory Doolan, Robin B Gasser, Nicola Laraine Harris and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Evaluation of Serum Supplementation on the Development ofInternational journal of molecular sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Anthony MarchandLaboratory of Intestinal Immunology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID 0000-0003-2864-0408
Joyce W M Van BreeDepartment of Immunology and Pathology, Alfred Medical Research and Education Precinct (AMREP), Monash University, Melbourne, VIC 3004, Australia.
Aya C TakiMelbourne Veterinary School, The University of Melbourne, Melbourne, VIC 3052, Australia.ORCID 0000-0003-3489-4367
Mati MoyatLaboratory of Intestinal Immunology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Gerardo TurcattiBiomolecular Screening Facility, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID 0000-0003-0139-223X
Marc ChambonBiomolecular Screening Facility, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Adam Alexander Thil SmithMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.ORCID 0000-0003-4593-3042
Rory DoolanHookworm Immuno-Biology Laboratory, Swiss Tropical and Public Health Institute, 4123 Allschwill, Switzerland.
Robin B GasserMelbourne Veterinary School, The University of Melbourne, Melbourne, VIC 3052, Australia.ORCID 0000-0002-4423-1690
Nicola Laraine HarrisLaboratory of Intestinal Immunology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID 0000-0003-2922-0210
Tiffany BoucheryLaboratory of Intestinal Immunology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
École Polytechnique Fédérale de Lausanne · CHSwiss Tropical and Public Health Institute · CHThe University of Melbourne · AUBaker Heart and Diabetes Institute · AUMonash University · AU

Funding

Australian Research Council DP210101500Australian Research Council LP180101085Australian Research Council LP190101209European Society of Clinical Microbiology and Infectious Diseases Research Grant 2017National Health and Medical Research Council National Health and Medical Research Council (NHMRC) SRF-BSwiss National Science Foundation national project NCCR-Chemical BiologySwiss National Science Foundation PR00P3_193084
6 · The paper itself

Abstract

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and their need to feed on host blood, resulting in a loss of iron and protein, which can lead to severe anaemia and impaired cognitive development in children. Currently, only one drug, albendazole is efficient to treat hookworm infection and the scientific community fears the rise of resistant strains. As part of on-going efforts to control hookworm infections and its associated morbidities, new drugs are urgently needed. We focused on targeting the blood-feeding pathway, which is essential to the parasite survival and reproduction, using the laboratory hookworm model

Indexed as

blood-feedingdrug-screeningfluorescencehelminthhookwormmotilityviability

Identifiers

PMID35745589
PMCPMC9231213
OpenAlexW4281692587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.