Evidence map›Paper›PMID 35745587›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes.

Maria Grazia Perrone, Paola Vitale, Morena Miciaccia, Savina Ferorelli, Antonella Centonze, Roberta Solidoro, Cristina Munzone, Carmela Bonaccorso, Cosimo Gianluca Fortuna, Katrin Kleinmanns and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Mitochondrial Protease ClpP: Cancer Marker and Drug Target.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  2. Review
  3. Exosomes in Ovarian Cancer: Towards Precision Oncology.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Maria Grazia PerroneDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125 Bari, Italy.ORCID 0000-0003-4195-5228
Paola VitaleDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125 Bari, Italy.ORCID 0000-0001-8132-2893
Morena MiciacciaDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125 Bari, Italy.ORCID 0000-0002-0727-6435
Savina FerorelliDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125 Bari, Italy.
Antonella CentonzeDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125 Bari, Italy.ORCID 0000-0003-3318-2704
Roberta SolidoroDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125 Bari, Italy.
Cristina MunzoneDepartment of Chemical Science, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
Carmela BonaccorsoDepartment of Chemical Science, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy.ORCID 0000-0001-9112-5623
Cosimo Gianluca FortunaDepartment of Chemical Science, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
Katrin KleinmannsCentre for Cancer Biomarkers (CCBio), Department of Clinical Science, University of Bergen, Jonas Lies vei, 5021 Bergen, Norway.ORCID 0000-0003-1402-8568
Line BjørgeCentre for Cancer Biomarkers (CCBio), Department of Clinical Science, University of Bergen, Jonas Lies vei, 5021 Bergen, Norway.ORCID 0000-0002-0240-2770
Antonio ScilimatiDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125 Bari, Italy.ORCID 0000-0003-2740-6425
University of Bari Aldo Moro · ITUniversity of Catania · ITHaukeland University Hospital · NOUniversity of Bergen · NO

Funding

Italian Association for Cancer Research 17566Ministry of Economic Development 092
6 · The paper itself

Abstract

The identification and removal of all gross and microscopic tumor to render the patient disease free represents a huge challenge in ovarian cancer treatment. The presence of residual disease is an independent negative prognostic factor. Herein, we describe the synthesis and the "in vitro" evaluation of compounds as cyclooxygenase (COX)-1 inhibitors, the COX-1 isoform being an ovarian cancer biomarker, each bearing fluorochromes with different fluorescence features. Two of these compounds

Indexed as

COX-1 and COX-2 selective inhibitorsfluorescent probesmofezolacovarian cancertumor-targeted imaging

Identifiers

PMID35745587
PMCPMC9230671
OpenAlexW4281809375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.