Evidence map›Paper›PMID 35745497›Full record

ArticlePathogens (Basel, Switzerland)2022

Treatment Reducing Endothelial Activation Protects against Experimental Cerebral Malaria.

Sabrina Mota, Johanna Bensalel, Do Hee Park, Sandra Gonzalez, Ana Rodriguez, Julio Gallego-Delgado

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. The therapeutic potential of atorvastatin in treatment ofFrontiers in veterinary science · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Exploring adjunctive therapies for cerebral malaria.Frontiers in cellular and infection microbiology · 2024
    Review
  7. Pathology of Severe Malaria.Pathogens (Basel, Switzerland) · 2023
    Article
  8. Antiplasmodial, Trypanocidal, and GenotoxicityPharmaceuticals (Basel, Switzerland) · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sabrina MotaDepartment of Microbiology, New York University School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-5472-6283
Johanna BensalelDepartment of Biological Sciences, Lehman College, The City University of New York, Bronx, New York, NY 10468, USA.
Do Hee ParkDepartment of Microbiology, New York University School of Medicine, New York, NY 10016, USA.
Sandra GonzalezDepartment of Microbiology, New York University School of Medicine, New York, NY 10016, USA.
Ana RodriguezDepartment of Microbiology, New York University School of Medicine, New York, NY 10016, USA.
Julio Gallego-DelgadoDepartment of Biological Sciences, Lehman College, The City University of New York, Bronx, New York, NY 10468, USA.ORCID 0000-0002-8914-7740
New York University · USThe Graduate Center, CUNY · US

Funding

Beta-catenin signaling in endothelial cells during cerebral malariaR01HL130630 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHER, EDWARD A, RODRIGUEZ, ANA · 2015 to 2018
$2.1M
Targeting the compromised brain endothelial barrier function during cerebral malaria with AT2 receptor agonistsR01HL150145 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RODRIGUEZ, ANA, STITT, ALAN · 2020 to 2023
$2.0M
Regulation of brain endothelial integrity by angiotensin receptors as treatment for cerebral malariaR01NS105910 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RODRIGUEZ, ANA, WALTHER, THOMAS · 2018 to 2022
$1.6M
New strategies to study malaria-induced acute kidney injurySC2GM144168 · NIGMS · HERBERT H. LEHMAN COLLEGE · PI GALLEGO-DELGADO, JULIO · 2021 to 2023
$468k
National Heart Lung and Blood Institute 1R01HL130630National Heart Lung and Blood Institute 1R01HL150145NHLBI NIH HHS R01 HL130630NHLBI NIH HHS R01 HL150145NIGMS NIH HHS 1SC2GM144168NIGMS NIH HHS SC2 GM144168NINDS NIH HHS 1R01NS105910NINDS NIH HHS R01 NS105910PSC-CUNY Award cycle 51 63445-00 51
6 · The paper itself

Abstract

Cerebral malaria (CM) is the most severe neurological complication of malaria caused by

Indexed as

adjunctive therapyARBsbiomarkerscerebral malariaendothelial activationstatins

Identifiers

PMID35745497
PMCPMC9229727
OpenAlexW4281904875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.