Evidence map›Paper›PMID 35745381›Full record

ArticleNanomaterials (Basel, Switzerland)2022

Magnetic Nanoclusters Increase the Sensitivity of Lateral Flow Immunoassays for Protein Detection: Application to Pneumolysin as a Biomarker for

María Salvador, José Luis Marqués-Fernández, Alexander Bunge, José Carlos Martínez-García, Rodica Turcu, Davide Peddis, María Del Mar García-Suárez, María Dolores Cima-Cabal, Montserrat Rivas

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

María SalvadorDepartment of Physics & IUTA, University of Oviedo, Campus de Viesques, 33203 Gijón, Spain.ORCID 0000-0002-6865-7397
José Luis Marqués-FernándezDepartment of Physics & IUTA, University of Oviedo, Campus de Viesques, 33203 Gijón, Spain.ORCID 0000-0003-2321-3634
Alexander BungeNational Institute for Research and Development of Isotopic and Molecular Technologies, 400293 Cluj-Napoca, Romania.
José Carlos Martínez-GarcíaDepartment of Physics & IUTA, University of Oviedo, Campus de Viesques, 33203 Gijón, Spain.ORCID 0000-0002-9562-3934
Rodica TurcuNational Institute for Research and Development of Isotopic and Molecular Technologies, 400293 Cluj-Napoca, Romania.ORCID 0000-0002-6355-8381
Davide PeddisInstitute of Structure of Matter-National Research Council (CNR), 00016 Monterotondo Scalo (RM), Rome, Italy.
María Del Mar García-SuárezEscuela Superior de Ingeniería y Tecnología (ESIT), Universidad Internacional de la Rioja (UNIR), Avenida de la Paz, 137, 26006 Logroño, Spain.ORCID 0000-0002-5920-3393
María Dolores Cima-CabalEscuela Superior de Ingeniería y Tecnología (ESIT), Universidad Internacional de la Rioja (UNIR), Avenida de la Paz, 137, 26006 Logroño, Spain.ORCID 0000-0002-5534-3364
Montserrat RivasDepartment of Physics & IUTA, University of Oviedo, Campus de Viesques, 33203 Gijón, Spain.ORCID 0000-0002-2186-0574
Universidad de Oviedo · ESNational Institute for Research and Development of Isotopic and Molecular Technologies · ROUniversidad Internacional De La Rioja · ESInstitute of Structure of Matter · IT

Funding

Consejería de Educación y Cultura del Gobierno del Principado de Asturias BP19-141Gobierno del Principado de Asturias FICYT/IDI/2021/000100Gobierno del Principado de Asturias FICYT/IDI/2021/000273Romanian Ministry of Research and Innovation Core Project PN-19-35-02-03Spanish Ministry of Economy and Competitiveness MCI-20-EIN2020-112354University of Oviedo, the Ministry of Education, Culture and Sport, and Banco Santander CEI15-24University Technological Institute of Asturias (IUTA) SV-21-GIJON-03
6 · The paper itself

Abstract

Lateral flow immunoassays for detecting biomarkers in body fluids are simple, quick, inexpensive point-of-care tests widely used in disease surveillance, such as during the coronavirus disease 2019 (COVID-19) pandemic. Improvements in sensitivity would increase their utility in healthcare, food safety, and environmental control. Recently, biofunctional magnetic nanoclusters have been used to selectively label target proteins, which allows their detection and quantification with a magneto-inductive sensor. This type of detector is easily integrated with the lateral flow immunoassay format. Pneumolysin is a cholesterol-dependent cytolysin and one of the most important protein virulence factors of pneumonia produced by

Indexed as

COVID-19inductive sensorlateral flow immunoassaysmagnetic nanoparticlesmagnetic separationpneumococcal pneumonia

Identifiers

PMID35745381
PMCPMC9228753
OpenAlexW4282926375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.