Evidence map›Paper›PMID 35745361›Full record

ArticleNanomaterials (Basel, Switzerland)2022

Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition.

Li Xia, Saeed Alqahtani, Christina R Ferreira, Uma K Aryal, Katelyn Biggs, Jonathan H Shannahan

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. The Opposite Roles of Benzo[Environment & health (Washington, D.C.) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Pulmonary iron oxide (FeHuman & experimental toxicology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Li XiaSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN 47907, USA.
Saeed AlqahtaniSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-9959-9732
Christina R FerreiraPurdue Metabolite Profiling Facility, Purdue University, West Lafayette, IN 47907, USA.
Uma K AryalPurdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0003-4543-1536
Katelyn BiggsSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN 47907, USA.
Jonathan H ShannahanSchool of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN 47907, USA.
Purdue University West Lafayette · USKing Abdulaziz City for Science and Technology · SA

Funding

Compromised Resolution of Inflammation following Nanoparticle Exposure in Metabolic SyndromeR01ES033173 · NIEHS · PURDUE UNIVERSITY · PI Jonathan Henry Shannahan · 2022 to 2026
$1.7M
NIEHS NIH HHS R01 ES033173NIEHS NIH HHS R01ES033173
6 · The paper itself

Abstract

Nanoparticles (NPs) interact with biomolecules by forming a biocorona (BC) on their surface after introduction into the body and alter cell interactions and toxicity. Metabolic syndrome (MetS) is a prevalent condition and enhances susceptibility to inhaled exposures. We hypothesize that distinct NP-biomolecule interactions occur in the lungs due to MetS resulting in the formation of unique NP-BCs contributing to enhanced toxicity. Bronchoalveolar lavage fluid (BALF) was collected from healthy and MetS mouse models and used to evaluate variations in the BC formation on 20 nm iron oxide (Fe

Indexed as

bronchoalveolar lavage fluidinflammationinhalationiron oxide nanoparticlesmechanismsmetabolic syndromepulmonarysusceptibility

Identifiers

PMID35745361
PMCPMC9230893
OpenAlexW4282840552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.