ArticleNutrients2022
The Associations of Maternal Hemoglobin Concentration in Different Time Points and Its Changes during Pregnancy with Birth Weight Outcomes.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 20 citations in OpenAlex.
- Haemoglobin Concentrations and Maternal and Neonatal Outcomes: Identifying Optimal Haemoglobin Ranges.Paediatric and perinatal epidemiology · 2026Article
- Modeling the Association between Repeated Measures of Hemoglobin during Pregnancy and Adverse Birth Outcomes.The Journal of nutrition · 2026Article
- The associations of maternal liver biomarkers in different trimesters with birth weight outcomes.Scientific reports · 2026Article
- Changes in Maternal Hemoglobin Concentration and Risk of Low Birth Weight and Small-for-Gestational-Age in the United Arab Emirates: The Mutaba'ah Study.International journal of women's health · 2026Article
- The effects of China-recommended gestational weight gain guidelines and the Institute of Medicine guidelines on adverse birth outcomes: A population- based cohort study.European journal of clinical nutrition · 2025Article
- Relationship between serum ferritin and proinflammatory markers in late pregnancy: An exploratory analysis from Cartagena, ColombiaBiomedica : revista del Instituto Nacional de Salud · 2025Article
- Gestational weight trajectory and early offspring growth differed by gestational diabetes: a population-based cohort study.Nutrition & diabetes · 2025Article
- Machine learning approaches for predicting fetal macrosomia at different stages of pregnancy: a retrospective study in China.BMC pregnancy and childbirth · 2025Article
- Associations of hemoglobin trajectories and time in target hemoglobin range with adverse pregnancy outcomes: a real-world pregnancy records-based study.Frontiers in global women's health · 2025Article
- Hemoglobin concentrations in early pregnancy and their associations with adverse pregnancy outcomes in Western China: a population-based study.BMC pregnancy and childbirth · 2024Article
- First-trimester hemoglobin, haptoglobin genotype, and risk of gestational diabetes mellitus in a retrospective study among Chinese pregnant women.Nutrition & diabetes · 2024Article
- Breastfeeding, Gestational Diabetes Mellitus, Size at Birth and Overweight/Obesity in Early Childhood.Nutrients · 2024Article
- The associations of maternal liver biomarkers in early pregnancy with the risk of gestational diabetes mellitus: a prospective cohort study and Mendelian randomization analysis.Frontiers in endocrinology · 2024Article
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- Maternal hemoglobin change from early pregnancy to second trimester is associated with risk of gestational diabetes mellitus: a retrospective cohort study.Frontiers in nutrition · 2023Article
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- Change in Hemoglobin as Compared to Absolute Haemoglobin as a Determinant of Birth Weight: A Secondary Data Analysis From Eastern India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
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9 authors at 2 institutions in 1 country.
Funding
Abstract
Maternal hemoglobin (Hb) is related to nutritional status, which affects neonatal birth weight. However, it is very common for maternal Hb to fluctuate during pregnancy. To evaluate the associations of maternal Hb in different time points and its changes during pregnancy with neonatal birth weight, small for gestational age (SGA)/low birth weight (LBW) and large for gestational age (LGA)/macrosomia, we conducted this study by using data from the Electronic Medical Record System (EMRS) database of Zhoushan Maternal and Child Care Hospital in Zhejiang province, China. The pregnancy was divided into five periods: first, early-second, mediate-second, late-second, early-third and late-third trimesters; we further calculated the maternal Hb changes during pregnancy. Overall, the socio-demographic characteristics, health-related information and childbirth-related information of 24,183 mother−infant pairs were obtained. The average Hb concentration during the different periods were 123.95 ± 10.14, 117.95 ± 9.84, 114.31 ± 9.03, 113.26 ± 8.82, 113.29 ± 8.68 and 115.01 ± 8.85 g/L, respectively. Significant dose−response relationships between maternal Hb and birth weight were observed in the first, late-second and later trimesters (p non-linear < 0.05). Maternal Hb < 100 g/L was related to a high risk of LGA/macrosomia in the late-second (OR: 1.47, 95% CI: 1.18, 1.83) and later trimesters; additionally, high maternal Hb (>140 g/L) increased the risk of SGA/LBW in the first (OR: 1.26, 95% CI: 1.01, 1.57) and late-third trimesters (OR: 1.96, 95% CI: 1.20, 3.18). In addition, the increase in maternal Hb from the late-second to late-third trimesters had a positive correlation with SGA/LBW. In conclusion, maternal Hb markedly fluctuated during pregnancy; the negative dose−response association of maternal Hb in the late-second and third trimesters, and Hb change during pregnancy with neonatal birth weight outcomes were observed, respectively. Furthermore, the phenomenon of high Hb in the first trimester and after the late-second trimester and the increase of maternal Hb from the late-second to late-third trimesters more significantly increasing the risk of SGA/LBW should especially be given more attention. Its biological mechanism needs to be further explored.
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