Evidence map›Paper›PMID 35745259›Full record

Observational studyNutrients2022

Body Composition-Specific Asthma Phenotypes: Clinical Implications.

Xin Zhang, Ke Deng, Yulai Yuan, Lei Liu, Shuwen Zhang, Changyong Wang, Gang Wang, Hongping Zhang, Lei Wang, Gaiping Cheng and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin ZhangPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.
Ke DengDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.
Yulai YuanDepartment of Respiratory Medicine, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou 646699, China.
Lei LiuPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.
Shuwen ZhangPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.
Changyong WangDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.
Gang WangPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.
Hongping ZhangPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.
Lei WangPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.
Gaiping ChengDepartment of Clinical Nutrition, West China Hospital, Sichuan University, Chengdu 610044, China.
Lisa G WoodPriority Research Center for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2308, Australia.ORCID 0000-0002-0941-9225
Gang WangDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610044, China.

Funding

1.3.5 project for disciplines of excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University 2018HXFH016China Postdoctoral Science Foundation 2019M653437National Key Development Plan for Precision Medicine Research 2017YFC091004National Natural Science Foundation of China 81870027National Natural Science Foundation of China 81900026National Natural Science Foundation of China 81920108002Post-Doctor Research Project, West China Hospital, Sichuan University 2019HXBH066
6 · The paper itself

Abstract

backgroundPrevious studies have indicated the limitations of body mass index for defining disease phenotypes. The description of asthma phenotypes based on body composition (BC) has not been largely reported.

objectiveTo identify and characterize phenotypes based on BC parameters in patients with asthma.

methodsA study with two prospective observational cohorts analyzing adult patients with stable asthma (

resultsThree clusters had significantly different characteristics associated with asthma outcomes. An external validation identified the similarity of the participants in training and the validation set. In the training set, cluster Training (T) 1 (29.4%) was "patients with undernutrition", cluster T2 (18.9%) was "intermediate level of nutrition with psychological dysfunction", and cluster T3 (51.8%) was "patients with good nutrition". Cluster T3 had a decreased risk of moderate-to-severe and severe AEs in the following year compared with the other two clusters. The most important BC-specific factors contributing to being accurately assigned to one of these three clusters were skeletal muscle mass and visceral fat area.

conclusionWe defined three distinct clusters of asthma patients, which had distinct clinical features and asthma outcomes. Our data reinforced the importance of evaluating BC to determining nutritional status in clinical practice.

Indexed as

AsthmaBody CompositionCluster AnalysisHumansPhenotypeSeverity of Illness Indexasthmabody compositionnutritional statusphenotypeskeletal muscle mass

Identifiers

PMID35745259
PMCPMC9229860

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.