Evidence map›Paper›PMID 35745081›Full record

ArticleMolecules (Basel, Switzerland)2022

Design, Synthesis and Cytotoxic Activity Evaluation of Newly Synthesized Amides-Based TMP Moiety as Potential Anticancer Agents over HepG2 Cells.

Tarfah Al-Warhi, Adil Aldhahrani, Fayez Althobaiti, Eman Fayad, Ola A Abu Ali, Sarah Albogami, Ali H Abu Almaaty, Amgad I M Khedr, Syed Nasir Abbas Bukhari, Islam Zaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tarfah Al-WarhiDepartment of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Adil AldhahraniClinical Laboratory Sciences Department, Turabah University Faculty, Taif University, Taif 21995, Saudi Arabia.
Fayez AlthobaitiDepartment of Biotechnology, Faculty of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Eman FayadDepartment of Biotechnology, Faculty of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-2916-0254
Ola A Abu AliDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099 Taif 21944, Saudi Arabia.
Sarah AlbogamiDepartment of Biotechnology, Faculty of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0003-0774-5550
Ali H Abu AlmaatyZoology Department, Faculty of Science, Port Said University, Port Said 42526, Egypt.ORCID 0000-0001-9056-0228
Amgad I M KhedrDepartment of Pharmacognosy, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.
Syed Nasir Abbas BukhariDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.ORCID 0000-0001-8125-7972
Islam ZakiPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.ORCID 0000-0002-2026-7373

Funding

Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2022R25), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia PNURSP2022R25
6 · The paper itself

Abstract

A novel series of amides based TMP moiety was designed, synthesized and evaluated for their antiproliferative as well as enzyme inhibition activity. Compounds

Indexed as

AmidesAntineoplastic AgentsApoptosisCaspase 3Cell Line, TumorCell ProliferationDrug DesignDrug Screening Assays, AntitumorHep G2 CellsHumansStructure-Activity RelationshipAmidesAntineoplastic AgentsCaspase 3Annexin VcaspasediamideHDACMMPtetraamideTMPtriamidetubulin

Identifiers

PMID35745081
PMCPMC9227250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.