Benzamides Substituted with Quinoline-Linked 1,2,4-Oxadiazole: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo.

Bin-Long Sun, Ying-Ying Wang, Sen Yang, Min-Ting Tu, Ying-Ying Shao, Yi Hua, Yi Zhou, Cheng-Xia Tan

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Benzimidazole-Quinoline Hybrids: Synthesis and Antimicrobial Properties.Pharmaceuticals (Basel, Switzerland) · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bin-Long SunCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Ying-Ying WangCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Sen YangCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Min-Ting TuCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Ying-Ying ShaoCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Yi HuaCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Yi ZhouCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Cheng-Xia TanCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0003-1000-8578

Funding

Siga Co. Ltd. R&D Program KYY-HX-20210049Wynca Group KYY-HX-20200138

6 · The paper itself

Abstract

To develop new compounds with high activity, broad spectrum and low-toxicity, 17 benzamides substituted with quinoline-linked 1,2,4-oxadiazole were designed using the splicing principle of active substructures and were synthesized. The biological activities were evaluated against 10 fungi, indicating that some of the synthetic compounds showed excellent fungicidal activities. For example, at 50 mg/L, the inhibitory activity of

Indexed as

AscomycotaFungicides, IndustrialQuinolinesAnimalsBenzamidesMolecular StructureOxadiazolesStructure-Activity RelationshipZebrafishBenzamidesFungicides, IndustrialOxadiazolesQuinolines1,2,4-oxadiazolebiological activityquinolinesynthesistoxicity

Identifiers

PMID35745068

DOI10.3390/molecules27123946

PMCPMC9229796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.