Evidence map›Paper›PMID 35744904›Full record

ArticleMolecules (Basel, Switzerland)2022

Lei Wang, Zhengxing Zhang, Helen Merkens, Jutta Zeisler, Chengcheng Zhang, Aron Roxin, Ruiyan Tan, François Bénard, Kuo-Shyan Lin

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. NovelPharmaceuticals (Basel, Switzerland) · 2025
    Article
  5. Synthesis and Evaluation ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  6. Synthesis and Evaluation of the FirstMolecules (Basel, Switzerland) · 2024
    Article
  7. Synthesis and Evaluation of NovelPharmaceuticals (Basel, Switzerland) · 2024
    Article
  8. Article
  9. Advances of radiolabeled GRPR ligands for PET/CT imaging of cancers.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  10. Article
  11. Article
  12. Molecules (Basel, Switzerland) · 2023
    Article
  13. Optimization of the Pharmacokinetic Profile of [Pharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lei WangDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Zhengxing ZhangDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Helen MerkensDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Jutta ZeislerDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Chengcheng ZhangDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Aron RoxinDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Ruiyan TanDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-7195-4368
François BénardDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.
Kuo-Shyan LinDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-0739-0780
University of British Columbia · CA

Funding

China Scholarship Council 202008310216CIHR FDN-148465, PJT-162243, PJT-180299 and PJT-180300
6 · The paper itself

Abstract

The gastrin-releasing peptide receptor (GRPR) is a G-protein-coupled receptor that is overexpressed in many solid cancers and is a promising target for cancer imaging and therapy. However, high pancreas uptake is a major concern in the application of reported GRPR-targeting radiopharmaceuticals, particularly for targeted radioligand therapy. To lower pancreas uptake, we explored Ga-complexed TacsBOMB2, TacsBOMB3, TacsBOMB4, TacsBOMB5, and TacsBOMB6 derived from a potent GRPR antagonist sequence, [Leu

Indexed as

BombesinReceptors, BombesinAnimalsCell Line, TumorGallium RadioisotopesHumansPancreasPositron-Emission TomographyRadiopharmaceuticalsBombesinGallium RadioisotopesRadiopharmaceuticalsReceptors, Bombesingallium-68gastrin-releasing peptide receptorpancreas uptakepositron-emission tomography

Identifiers

PMID35744904
PMCPMC9230575
OpenAlexW4282821689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.